| Interactions of water-soluble metalloporphyrins with nucleic acids studied by resonance Raman spectroscopy. | |
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MedLine Citation:
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PMID: 2973574 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The resonance Raman spectra of water-soluble porphyrins, M(TMpy-P4) (M = Cu(II), Ni(II) and Co(III] and their mixtures with poly(dG-dC)2, poly(dA-dT)2 and calf thymus and salmon DNAs were measured using a divided rotating cell to determine the magnitudes of frequency shift and intensity variation resulting from M(TMpy-P4)-nucleic acid interactions. Bands II(C beta-H bending, approximately 1100 cm-1) and VIII(C beta-C beta stretch, approximately 1570 cm-1) show a large and small upward shift, respectively, when Cu(TMpy-P4) and Ni(TMpy-P4) are intercalated at the G-C sites. In contrast, these bands show a small upward and downward shift, respectively, when Co(TMpy-P4) is groove-bound at the A-T sites of nucleic acids. Both Bands V (approximately 1260 cm-1) and IX (approximately 1646 cm-1) which originate in the N-methylpyridyl group always show small downward shifts due to coulombic interaction between the N-CH3+ group of TMpy-P4 and the PO2 group of the nucleic acid. |
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Authors:
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J H Schneider; J Odo; K Nakamoto |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Nucleic acids research Volume: 16 ISSN: 0305-1048 ISO Abbreviation: Nucleic Acids Res. Publication Date: 1988 Nov |
Date Detail:
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Created Date: 1989-01-05 Completed Date: 1989-01-05 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0411011 Medline TA: Nucleic Acids Res Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 10323-38 Citation Subset: IM |
Affiliation:
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Marquette University, Milwaukee, WI 53233. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Cobalt* Copper* DNA* Hematoporphyrin Derivative Hematoporphyrins Metalloporphyrins* Nickel* Polydeoxyribonucleotides* Spectrophotometry, Ultraviolet Spectrum Analysis, Raman / methods |
| Grant Support | |
ID/Acronym/Agency:
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GM-37608/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Hematoporphyrins; 0/Metalloporphyrins; 0/Polydeoxyribonucleotides; 68335-15-9/Hematoporphyrin Derivative; 7440-02-0/Nickel; 7440-48-4/Cobalt; 7440-50-8/Copper; 9007-49-2/DNA |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
| Full Text | |
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Journal Information Journal ID (nlm-ta): Nucleic Acids Res ISSN: 0305-1048 ISSN: 1362-4962 |
Article Information Download PDF  Print publication date: Day: 11 Month: 11 Year: 1988 Volume: 16 Issue: 21 First Page: 10323 Last Page: 10338 ID: 338854 PubMed Id: 2973574 |
| Interactions of water-soluble metalloporphyrins with nucleic acids studied by resonance Raman spectroscopy. | |
| J H Schneider | |
| J Odo | |
| K Nakamoto | |
| Marquette University, Milwaukee, WI 53233. |
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