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Interactions of oxygen at high pressure and radiation in Drosophila.
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MedLine Citation:
PMID:  5938826     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Oxygen at high pressure (OHP) and X-irradiation can interact in the fruit fly Drosophila melanogaster to potentiate toxic actions characteristic of one agent alone. 1000 kvp X-irradiation in doses of 30, 60, and 75 kr accelerated the acute immobilization of young male Drosophila by oxygen at 7.8 atm, up to rates twice that observed with such oxygen pressure alone. X-irradiation alone in these dosages did not acutely immobilize the Drosophila. X-irradiation during exposure to 7.8 atm pO(2) was more effective and consistent in producing this potentiation than was X-irradiation that preceded exposure to OHP. Acute OHP toxicity in young female Drosophila was not potentiated by 75 kr of X-irradiation. On the other hand, shortening of the life span of young male Drosophila by the above doses of X-irradiation was augmented significantly by a concurrent 40 min exposure to OHP (which alone did not significantly decrease life span). This shows, for the first time, that oxygen can affect not only the acute effects of radiation, but also the residual irreversible effects indicated by the life span shortening.
Authors:
J J Thomas; R C Baxter; W O Fenn
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  The Journal of general physiology     Volume:  49     ISSN:  0022-1295     ISO Abbreviation:  J. Gen. Physiol.     Publication Date:  1966 Jan 
Date Detail:
Created Date:  1966-09-21     Completed Date:  1966-09-21     Revised Date:  2010-06-22    
Medline Journal Info:
Nlm Unique ID:  2985110R     Medline TA:  J Gen Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  537-49     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Drosophila / radiation effects*
Hyperbaric Oxygenation*
Radiation Effects*
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Full Text
Journal Information
Journal ID (nlm-ta): J Gen Physiol
ISSN: 0022-1295
ISSN: 1540-7748
Publisher: The Rockefeller University Press
Article Information
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Copyright © 1966 by The Rockefeller University Press
Received Day: 22 Month: 3 Year: 1965
Print publication date: Day: 1 Month: 1 Year: 1966
Volume: 49 Issue: 3
First Page: 537 Last Page: 549
ID: 2195499
PubMed Id: 5938826

Interactions of Oxygen at High Pressure and Radiation in Drosophila
J.J. Thomas, Jr.
R.C. Baxter
W.O. Fenn
From the Departments of Physiology and Radiation Biology, University of Rochester Medical Center, Rochester, New York


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