| Interactions of the malaria parasite and its mammalian host. | |
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MedLine Citation:
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PMID: 18644249 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A hallmark of Plasmodium development inside its mammalian victim is the remarkable restriction to the host species. Adaptation to an intracellular life style in specific target cells is determined by multiple parasite-host interactions. The first line of crosstalk occurs during intradermal sporozoite injection by an Anopheles mosquito. The following expansion in the liver is highly efficient and leads to successful establishment of the parasite population. During the periodic waves of fevers and chills the parasite destroys and re-infects red blood cells. Recent advances in experimental genetics and imaging techniques begin to expose the complex interactions at the changing parasite-host interfaces. Understanding the cellular and molecular mechanisms of target cell recognition, nutrient acquisition, and hijacking of cellular and immune functions may ultimately explain the elaborate biology of a medically important single cell eukaryote. |
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Authors:
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Olivier Silvie; Maria M Mota; Kai Matuschewski; Miguel Prudêncio |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Current opinion in microbiology Volume: 11 ISSN: 1369-5274 ISO Abbreviation: Curr. Opin. Microbiol. Publication Date: 2008 Aug |
Date Detail:
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Created Date: 2008-08-12 Completed Date: 2008-10-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9815056 Medline TA: Curr Opin Microbiol Country: England |
Other Details:
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Languages: eng Pagination: 352-9 Citation Subset: IM |
Affiliation:
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Department of Parasitology, Heidelberg University School of Medicine, Heidelberg, Germany. Olivier.Silvie@med.uni-heidelberg.de |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Erythrocytes / parasitology Host-Parasite Interactions* Humans Liver / parasitology Malaria / parasitology* Mammals Plasmodium / physiology* Skin / parasitology |
| Grant Support | |
ID/Acronym/Agency:
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//Howard Hughes Medical Institute |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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