| Interactions in the behavioral effects of methylxanthines and adenosine derivatives. | |
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MedLine Citation:
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PMID: 6194284 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The role of adenosine receptors in behavioral effects of alkylxanthines was evaluated in mice. The relative potencies of alkylxanthines in reversing locomotor activity depression elicited by L-phenylisopropyladenosine (L-PIA) were similar to relative potencies in competing for adenosine receptors labeled by [3H]cyclohexyladenosine. Whereas L-PIA at i.p. doses of 0.10 mumol/kg and higher depressed locomotor activity, lower doses (0.01 and 0.05 mumol/kg) augmented locomotor activity. At the doses evaluated, caffeine did not further augment the L-PIA (0.05 mumol/kg)-enhanced locomotor activity. Low doses of diazepam, like L-PIA, augmented locomotor activity. Combining locomotor depressant doses of diazepam and caffeine produced a paradoxical stimulation of activity, as observed also for L-PIA and caffeine. Low doses of diazepam but not L-PIA increased crossings between the light and dark sites in a shuttle box, indicating a difference in the behavioral profile of these two agents. At behaviorally effective doses, L-PIA did not alter blood pressure or heart rate, but elicited some premature ventricular contractions which, however, occurred to a similar extent at locomotor depressant and stimulant doses of L-PIA. Brain levels of L-PIA at the lowest behaviorally active doses were adequate to occupy more than 50% of adenosine receptors. Thus, the behavioral effects of L-PIA appeared to be mediated in the brain and were not secondary to the cardiovascular effects. |
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Authors:
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J J Katims; Z Annau; S H Snyder |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The Journal of pharmacology and experimental therapeutics Volume: 227 ISSN: 0022-3565 ISO Abbreviation: J. Pharmacol. Exp. Ther. Publication Date: 1983 Oct |
Date Detail:
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Created Date: 1983-11-23 Completed Date: 1983-11-23 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0376362 Medline TA: J Pharmacol Exp Ther Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 167-73 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenosine
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analogs & derivatives*,
pharmacology Animals Blood Pressure / drug effects Brain / drug effects Caffeine / pharmacology Cardiac Complexes, Premature / chemically induced Diazepam / pharmacology* Drug Interactions Heart Rate / drug effects Male Mice Mice, Inbred ICR Motor Activity / drug effects* Phenylisopropyladenosine / pharmacology* Receptors, Cell Surface / drug effects Receptors, Purinergic Stimulation, Chemical Xanthines / pharmacology* |
| Grant Support | |
ID/Acronym/Agency:
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DA-00266/DA/NIDA NIH HHS; MH-18501/MH/NIMH NIH HHS; NS-16375/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Receptors, Cell Surface; 0/Receptors, Purinergic; 0/Xanthines; 29193-86-0/Phenylisopropyladenosine; 439-14-5/Diazepam; 58-08-2/Caffeine; 58-61-7/Adenosine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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