Document Detail

Interactions of helium, oxygen, and nitrous oxide affecting bacterial growth.
MedLine Citation:
PMID:  97828     Owner:  NLM     Status:  MEDLINE    
Helium at pressures of 20 to 70 atm in the presence of air found to stimulate growth of Streptococcus faecalis, Escherichia coli, and Staphylococcus aureus, mainly by increasing the rate of exponential growth. However, at these same pressures, helium potentiated the growth-inhibitory actions of oxygen and nitrous oxide (N2O). Oxygen was found to act essentially as an anesthetic gas in inhibiting growth of S. faecalis; its potency was approximately the same as that of N2O, and it acted additively in combination with N2O to inhibit the streptococcus. Oxygen proved to be more potent than N2O in inhibiting the growth of E. coli and S. aureus, and each gas potentiated the action of the other. Oxygen sensitivity was correlated with N2O sensitivity. Overall, our findings indicate that bacterial growth inhibition by anesthetic gases does not accurately reflect narcotic action.
R E Marquis; S R Thom; C A Crookshank
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Undersea biomedical research     Volume:  5     ISSN:  0093-5387     ISO Abbreviation:  Undersea Biomed Res     Publication Date:  1978 Jun 
Date Detail:
Created Date:  1978-09-29     Completed Date:  1978-09-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0421514     Medline TA:  Undersea Biomed Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  189-98     Citation Subset:  IM; S    
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MeSH Terms
Bacteria / drug effects,  growth & development*
Drug Synergism
Enterococcus faecalis / drug effects,  growth & development
Escherichia coli / drug effects,  growth & development
Helium / pharmacology*
Nitrous Oxide / pharmacology*
Oxygen / pharmacology*
Staphylococcus aureus / drug effects,  growth & development
Reg. No./Substance:
10024-97-2/Nitrous Oxide; 7440-59-7/Helium; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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