| Interactions of the complement system with molecules of extracellular matrix: Relevance for joint diseases. | |
| | |
MedLine Citation:
|
PMID: 22964234 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Rheumatoid arthritis (RA) is a highly disabling disease affecting all structures of the joint. Understanding the pathology behind the development of RA is essential for developing targeted therapeutic strategies as well as for developing novel markers to predict disease onset. Several molecules normally hidden within the cartilage tissue are exposed to complement components in the synovial fluid upon cartilage breakdown. Some of these have been shown to activate complement and toll-like receptors, which may enhance an already existing inflammatory response, thereby worsening the course of disease. Other cartilage-resident molecules have in contrast shown to possess complement-inhibitory properties. Knowledge about mechanisms behind pathological complement activation in the joints will hopefully lead to methods which allow us to distinguish patients with pathological complement activation from those where other inflammatory pathways are predominant. This will help to elucidate which patients will benefit from complement inhibitory therapies, which are thought to aid a specific subset of patients or patients at a certain stage of disease. Future challenges are to target the complement inhibition specifically to the joints to minimize systemic complement blockade. |
| | |
Authors:
|
Kaisa E Happonen; Dick Heinegård; Tore Saxne; Anna M Blom |
Related Documents
:
|
2789264 - A study of morbidity pattern among prostitutes attending a municipal clinic in pune. 20011264 - Sexually transmitted parasitic diseases. 18677144 - New approaches to external genital warts and vulvar intraepithelial neoplasia. 3090904 - Risk of transmission of sexually transmitted diseases by cryopreserved semen. 15314264 - Transforming growth factor-beta signaling pathway as a therapeutic target in neurodegen... 15825124 - Genetic testing: who should do the testing and what is the role of genetic testing in t... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Immunobiology Volume: 217 ISSN: 1878-3279 ISO Abbreviation: Immunobiology Publication Date: 2012 Nov |
Date Detail:
|
Created Date: 2012-09-11 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8002742 Medline TA: Immunobiology Country: Netherlands |
Other Details:
|
Languages: eng Pagination: 1088-96 Citation Subset: IM |
Copyright Information:
|
Copyright © 2012 Elsevier GmbH. All rights reserved. |
Affiliation:
|
Department of Laboratory Medicine, Division of Medical Protein Chemistry, Wallenberg Laboratory, Skåne University Hospital, Lund University, Sweden. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Paroxysmal nocturnal hemoglobinuria and other complement-mediated hematological disorders.
Next Document: Targeted complement inhibition as a promising strategy for preventing inflammatory complications in ...