Document Detail

Interactions of borderline personality disorder and mood disorders over 10 years.
MedLine Citation:
PMID:  25007118     Owner:  NLM     Status:  Publisher    
OBJECTIVE: To examine the relationship of borderline personality disorder (BPD) to mood disorders by using data from the Collaborative Longitudinal Personality Disorders Study on the reciprocal interactions of BPD with both depressive and bipolar disorders over the course of 10 years.
METHOD: The study included 223 BPD patients with DSM-IV-defined co-occurring major depressive disorder (MDD) (n = 161), bipolar I disorder (n = 34), and bipolar II disorder (n = 28) who were reliably and prospectively assessed over a period of 10 years between 1997 and 2009. Proportional hazards regression analyses were used to assess the effects of improvement or worsening of BPD and mood disorders on each disorder's time to remission and time to relapse.
RESULTS: Borderline personality disorder and MDD had strong and statistically significant reciprocal effects, delaying each disorder's time to remission (BPD's effect on MDD, P = .0004; MDD's effect on BPD, P = .0002) and accelerating time to relapse (BPD's effect on MDD, P = .0410; MDD's effect on BPD, P = .0011), whereas BPD and the bipolar disorders were largely independent disorders except that bipolar II lengthened BPD's time to remission (P = .0085).
CONCLUSIONS: Borderline personality disorder and MDD interactions suggest overlap in their psychopathologies and argue for prioritizing the treatment of BPD. Borderline personality disorder and bipolar disorders appear to be independent disorders, underscoring the need to provide appropriate treatment for each.
John G Gunderson; Robert L Stout; M Tracie Shea; Carlos M Grilo; John C Markowitz; Leslie C Morey; Charles Sanislow; Shirley Yen; Mary C Zanarini; Alex S Keuroghlian; Thomas H McGlashan; Andrew E Skodol
Related Documents :
24308278 - Recognition, diagnosis and treatment of postpartum bipolar depression.
24330948 - Dysfunctional cognitions among offspring of individuals with bipolar disorder.
20108458 - The functional sphincter of oddi disorder.
23122528 - Quantitative heel ultrasound (qus) measures of bone quality in association with mood an...
2101408 - Soluble interleukin-2 receptors in pulmonary tuberculosis.
18834968 - A connective tissue disorder caused by mutations of the lysyl hydroxylase 3 gene.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-6-10
Journal Detail:
Title:  The Journal of clinical psychiatry     Volume:  -     ISSN:  1555-2101     ISO Abbreviation:  J Clin Psychiatry     Publication Date:  2014 Jun 
Date Detail:
Created Date:  2014-7-9     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7801243     Medline TA:  J Clin Psychiatry     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© Copyright 2014 Physicians Postgraduate Press, Inc.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Aza-Crown-Ether-Appended Xanthene: Selective Ratiometric Fluorescent Probe for Silver(I) Ion Based o...
Next Document:  MS Transport Assays for ?-aminobutyric acid transporters - an efficient alternative for radiometric ...