| Interactions of body fat and muscle mass with substrate concentrations and fasting insulin levels in adults with growth hormone deficiency. | |
| | |
MedLine Citation:
|
PMID: 7924165 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
1. Adults with growth hormone deficiency have an abnormal body composition. Alterations in body composition are closely related to substrate concentrations and insulin action. The lack of growth hormone has been associated with increased insulin sensitivity. 2. We investigated the correlations of body composition with fasting insulin levels and substrate concentrations in 24 adults with growth hormone deficiency over a wide range of adiposity (body mass index 18.8-42.3 kg/m2). 3. Lean body mass was measured by total body potassium, computer tomography of the thigh and urinary creatinine excretion. Muscle fibre distribution was evaluated from vastus lateralis biopsies. Fat mass was assessed by skinfold thickness measurements, computer tomography of the thigh, and waist and hip girth. 4. Fasting plasma insulin level increased with fat mass (r = 0.67, P = 0.0004) and with waist girth (r = 0.76, P = 0.0001). Fasting plasma insulin level increased with fasting plasma glucose level (r = 0.53, P = 0.01). Fasting plasma glucose level in turn was positively correlated with lean body mass (r = 0.49, P = 0.01) and with total thigh muscle area (r = 0.54, P = 0.01). There was no correlation between lean body mass and fat mass (r = 0.17, not significant) nor between muscle fibre types and fat mass or fat distribution. Fasting plasma insulin level showed no correlation with any measurement of lean body mass or muscle fibre type.(ABSTRACT TRUNCATED AT 250 WORDS) |
| | |
Authors:
|
F Salomon; R C Cuneo; A M Umpleby; P H Sönksen |
Related Documents
:
|
16919625 - Role of aquaporin-7 in the pathophysiological control of fat accumulation in mice. 7033275 - Relation of body fat distribution to metabolic complications of obesity. 8266385 - Relation of carotid artery wall thickness to diabetes mellitus, fasting glucose and ins... 21779625 - The role of uncoupling protein 2 (ucp2) on the development of type 2 diabetes mellitus ... 9642655 - Hypoglycaemia during intensified insulin therapy of children and adolescents. 8255835 - Microalbuminuria and coronary heart disease in non-diabetics. |
Publication Detail:
|
Type: Comparative Study; Journal Article |
Journal Detail:
|
Title: Clinical science (London, England : 1979) Volume: 87 ISSN: 0143-5221 ISO Abbreviation: Clin. Sci. Publication Date: 1994 Aug |
Date Detail:
|
Created Date: 1994-10-31 Completed Date: 1994-10-31 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 7905731 Medline TA: Clin Sci (Lond) Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 201-6 Citation Subset: IM |
Affiliation:
|
Department of Endocrinology and Chemical Pathology, United Medical School, Guy's Hospital, London, U.K. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Anthropometry Blood Glucose / metabolism Body Composition / physiology* C-Peptide / analysis Fasting / blood* Female Growth Hormone / deficiency* Humans Insulin / blood* Insulin-Like Growth Factor I / analysis Male Middle Aged Muscles / anatomy & histology Obesity / blood Thigh Time Factors |
| Chemical | |
Reg. No./Substance:
|
0/Blood Glucose; 0/C-Peptide; 11061-68-0/Insulin; 67763-96-6/Insulin-Like Growth Factor I; 9002-72-6/Growth Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Physiological and symptomatic responses to postural change in non-diabetic subjects during hypoglyca...
Next Document: Effect of sepsis on mucosal protein synthesis in different parts of the gastrointestinal tract in ra...