Document Detail

Interactions of body fat and muscle mass with substrate concentrations and fasting insulin levels in adults with growth hormone deficiency.
MedLine Citation:
PMID:  7924165     Owner:  NLM     Status:  MEDLINE    
1. Adults with growth hormone deficiency have an abnormal body composition. Alterations in body composition are closely related to substrate concentrations and insulin action. The lack of growth hormone has been associated with increased insulin sensitivity. 2. We investigated the correlations of body composition with fasting insulin levels and substrate concentrations in 24 adults with growth hormone deficiency over a wide range of adiposity (body mass index 18.8-42.3 kg/m2). 3. Lean body mass was measured by total body potassium, computer tomography of the thigh and urinary creatinine excretion. Muscle fibre distribution was evaluated from vastus lateralis biopsies. Fat mass was assessed by skinfold thickness measurements, computer tomography of the thigh, and waist and hip girth. 4. Fasting plasma insulin level increased with fat mass (r = 0.67, P = 0.0004) and with waist girth (r = 0.76, P = 0.0001). Fasting plasma insulin level increased with fasting plasma glucose level (r = 0.53, P = 0.01). Fasting plasma glucose level in turn was positively correlated with lean body mass (r = 0.49, P = 0.01) and with total thigh muscle area (r = 0.54, P = 0.01). There was no correlation between lean body mass and fat mass (r = 0.17, not significant) nor between muscle fibre types and fat mass or fat distribution. Fasting plasma insulin level showed no correlation with any measurement of lean body mass or muscle fibre type.(ABSTRACT TRUNCATED AT 250 WORDS)
F Salomon; R C Cuneo; A M Umpleby; P H Sönksen
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Clinical science (London, England : 1979)     Volume:  87     ISSN:  0143-5221     ISO Abbreviation:  Clin. Sci.     Publication Date:  1994 Aug 
Date Detail:
Created Date:  1994-10-31     Completed Date:  1994-10-31     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7905731     Medline TA:  Clin Sci (Lond)     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  201-6     Citation Subset:  IM    
Department of Endocrinology and Chemical Pathology, United Medical School, Guy's Hospital, London, U.K.
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MeSH Terms
Blood Glucose / metabolism
Body Composition / physiology*
C-Peptide / analysis
Fasting / blood*
Growth Hormone / deficiency*
Insulin / blood*
Insulin-Like Growth Factor I / analysis
Middle Aged
Muscles / anatomy & histology
Obesity / blood
Time Factors
Reg. No./Substance:
0/Blood Glucose; 0/C-Peptide; 11061-68-0/Insulin; 67763-96-6/Insulin-Like Growth Factor I; 9002-72-6/Growth Hormone

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