Document Detail

Interactions between vasopressin and food restriction on stress-induced analgesia.
MedLine Citation:
PMID:  8822511     Owner:  NLM     Status:  MEDLINE    
To investigate the role of the hormone vasopressin (VP) in mediating the response of an organism to food restriction stress-induced analgesia, tail flick latencies and scored qualitative behavioral responses were recorded in VP-containing (LE) rats and VP-deficient (DI) rats. These variables were measured under nonstressed (ad lib) and stressed (food restriction) conditions. In the ad lib condition, DI and LE rats had a similar tail flick latency and scored qualitative behavioral response to the stimulus eliciting the tail flick. During the food restriction condition, however, LE animals developed significant food restriction stress-induced analgesia, as measured by tail flick latency. On the other hand, DI animals did not develop significant analgesia. In addition, DI animals exhibited a significantly greater scored qualitative behavioral response to the stimulus eliciting the tail flick than LE animals. These results demonstrate that VP plays an important role in the regulation of food restriction stress-induced analgesia, as well as the scored qualitative behavioral response elicited by the tail flick stimulus.
C H Wideman; H M Murphy; S B McCartney
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Peptides     Volume:  17     ISSN:  0196-9781     ISO Abbreviation:  Peptides     Publication Date:  1996  
Date Detail:
Created Date:  1996-12-10     Completed Date:  1996-12-10     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8008690     Medline TA:  Peptides     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  63-6     Citation Subset:  IM    
Department of Biology, John Carroll University, Cleveland, OH 44118, USA.
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MeSH Terms
Food Deprivation / physiology*
Neurosecretory Systems / physiopathology
Pain / physiopathology*
Pain Measurement
Rats, Brattleboro
Stress, Physiological / physiopathology*
Vasopressins / physiology*
Reg. No./Substance:

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