Document Detail


Interactions between the sympathetic nervous system and the kidney: experimental observations.
MedLine Citation:
PMID:  3913755     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Increasing evidence suggests that the renal nerves may contribute to the pathogenesis of several types of experimental hypertension. It has been demonstrated that renal denervation can either attenuate the severity or delay the development of hypertension in spontaneously hypertensive rats (SHR), in DOCA-salt treated rats and in renovascular hypertensive rats. On the other hand, intrarenal administration of catecholamines has been shown to elicit an increase in systemic arterial pressure as long as the infusion is continued. The underlying mechanisms by which renal nerves might participate in the regulation of cardiovascular homeostasis have not been entirely clarified. It is known that efferent renal nerve activity, by exerting a direct influence on renal arteriolar tone, renin release and sodium and water excretion, can interfere with the control of arterial pressure by modifying peripheral resistances, circulating angiotensin II and volume balance. In addition, a role of afferent renal nerve activity in cardiovascular control and, possibly, in the pathogenesis of renovascular hypertension, has recently been proposed after the demonstration of mechano- and chemoreceptors inside the kidney. Indeed, blood pressure is reflexly influenced either by several manoeuvres applied to the kidney or by the electrical stimulation of afferent renal nerve fibres. Afferent and efferent renal nerve activity appear to be closely related since recent experiments by our group have provided further evidence of the existence of neural renorenal reflexes by which one kidney exerts a tonic inhibitory effect on the release of renin from juxtaglomerular cells and on tubular sodium and water reabsorption of the contralateral kidney.
Authors:
A Stella; A Zanchetti
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of hypertension. Supplement : official journal of the International Society of Hypertension     Volume:  3     ISSN:  0952-1178     ISO Abbreviation:  J Hypertens Suppl     Publication Date:  1985 Dec 
Date Detail:
Created Date:  1986-05-05     Completed Date:  1986-05-05     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8501422     Medline TA:  J Hypertens Suppl     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  S19-25     Citation Subset:  IM; S    
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MeSH Terms
Descriptor/Qualifier:
Afferent Pathways / physiology
Animals
Blood Pressure*
Chemoreceptor Cells / physiology
Denervation
Diuresis
Electric Stimulation
Kidney / innervation*,  physiology
Mechanoreceptors / physiology
Reflex / physiology
Renal Circulation
Renin / metabolism
Sympathetic Nervous System / physiology*
Vascular Resistance
Chemical
Reg. No./Substance:
EC 3.4.23.15/Renin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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