Document Detail

Interactions between serum creatinine, volume status, N-acetylcysteine, and contrast-induced nephropathy.
MedLine Citation:
PMID:  16703801     Owner:  NLM     Status:  MEDLINE    
Contrast-induced nephropathy is reported to be the third leading cause of acute renal failure. The development of contrast-induced nephropathy is associated with prolonged hospitalization, the potential need for renal replacement therapy, and increased mortality. N-acetylcysteine is commonly used for the prevention of contrast-induced nephropathy despite inconsistent results from numerous clinical trials and meta-analyses. The advantage of N-acetylcysteine in most studies was based on a decrease in the serum creatinine concentration and a decrease in oxidative stress. N-acetylcysteine itself can directly lower serum creatinine concentration without improving renal function, and hypovolemia can affect the oxidative stress. In most of the N-acetylcysteine studies, there are a lack of volume status and secondary end points. The value of N-acetylcysteine for the prevention of contrast-induced nephropathy seems questionable. The interactions between serum creatinine, N-Acetylcysteine, volume status, and the development of contrast-induced nephropathy were discussed in this letter.
Omer Toprak
Publication Detail:
Type:  Letter    
Journal Detail:
Title:  Renal failure     Volume:  28     ISSN:  0886-022X     ISO Abbreviation:  Ren Fail     Publication Date:  2006  
Date Detail:
Created Date:  2006-05-17     Completed Date:  2006-11-30     Revised Date:  2008-05-21    
Medline Journal Info:
Nlm Unique ID:  8701128     Medline TA:  Ren Fail     Country:  United States    
Other Details:
Languages:  eng     Pagination:  265-6     Citation Subset:  IM    
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MeSH Terms
Acetylcysteine / therapeutic use*
Blood Volume*
Contrast Media / adverse effects*
Creatinine / blood*
Kidney Diseases / chemically induced,  prevention & control*
Reg. No./Substance:
0/Contrast Media; 60-27-5/Creatinine; 616-91-1/Acetylcysteine

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