Document Detail


Interactions between protein and vegetable oils in the maternal diet determine the programming of the insulin axis in the rat.
MedLine Citation:
PMID:  17408526     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The available evidence suggests that metabolic control mechanisms are programmed early in life. Previous studies of pregnant rats fed low-protein diets have suggested that the vegetable oils used in the experimental diets influence the outcome. The present study investigated the offspring of female rats fed semi-synthetic diets containing either 180 or 90g casein/kg with 70 g/kg (w/w) of either corn oil or soya oil during gestation. During lactation, the dams received stock diet, and the offspring were subsequently weaned onto the stock diet. The offspring of dams fed the low-protein diets were smaller at birth. At 25 weeks of age, the offspring were subjected to an oral glucose tolerance test. In the offspring of dams fed the diet containing soya oil, the area under the insulin curve was affected by the protein content of the maternal diet. There was no effect of protein on the area under the insulin curve in the offspring of dams fed the diet prepared with corn oil. There were no differences in plasma glucose concentrations. The levels of mRNA for acetyl-CoA carboxylase- in the livers of female offspring were affected by the protein and oil content of the maternal diet. The level of carnitine palmitoyl transferase mRNA was affected by the protein content of the maternal diet. The present study suggests that PUFA in the maternal diet can interact with protein metabolism to influence the development of the offspring. This may involve the higher content of alpha-linolenic acid in soya oil compared with corn oil.
Authors:
Christopher A Maloney; Christina Lilley; Alicja Czopek; Susan M Hay; William D Rees
Related Documents :
15059186 - Modulation of neonatal immunological tolerance to ovalbumin by maternal essential fatty...
20437476 - Effect of maternal diet rich in omega-6 and omega-9 fatty acids on the liver of ldl rec...
24864296 - Effects of a dietary antioxidant blend and vitamin e on growth performance, oxidative s...
1754576 - Effects of protein-calorie malnutrition on transplacental kinetics of aminoisobutyric a...
20531176 - Irritable bowel syndrome: can nutrient manipulation help?
10678256 - Leptin responses to weight loss in postmenopausal women: relationship to sex-hormone bi...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The British journal of nutrition     Volume:  97     ISSN:  0007-1145     ISO Abbreviation:  Br. J. Nutr.     Publication Date:  2007 May 
Date Detail:
Created Date:  2007-09-05     Completed Date:  2007-11-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372547     Medline TA:  Br J Nutr     Country:  England    
Other Details:
Languages:  eng     Pagination:  912-20     Citation Subset:  IM    
Affiliation:
Rowett Research Institute, Greenburn Road, Bucksburn, Aberdeen, AB21 9SB, UK.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Acetyl-CoA Carboxylase / genetics
Amino Acids / analysis
Animals
Body Weight / physiology
Carnitine O-Palmitoyltransferase / genetics
Corn Oil / administration & dosage,  metabolism
Diet, Protein-Restricted / methods*
Dietary Fats, Unsaturated / administration & dosage,  metabolism*
Dietary Proteins / administration & dosage,  metabolism*
Eating / physiology
Female
Gene Expression / genetics
Glucose Tolerance Test
Hematocrit
Insulin / blood*
Insulin Resistance / physiology
Male
Maternal-Fetal Exchange / physiology
Organ Size / physiology
Plant Oils / administration & dosage,  metabolism*
Pregnancy
Rats
Rats, Inbred Strains
Sex Factors
Soybean Oil / administration & dosage,  metabolism
Chemical
Reg. No./Substance:
0/Amino Acids; 0/Dietary Fats, Unsaturated; 0/Dietary Proteins; 0/Plant Oils; 11061-68-0/Insulin; 8001-22-7/Soybean Oil; 8001-30-7/Corn Oil; EC 2.3.1.21/Carnitine O-Palmitoyltransferase; EC 6.4.1.2/Acetyl-CoA Carboxylase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  The minor allele of the PPARgamma2 pro12Ala polymorphism is associated with lower postprandial TAG a...
Next Document:  Undernutrition in early life and body composition of adolescent males from a birth cohort study.