| Interactions between protease inhibitors and acid-reducing agents: a systematic review. | |
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MedLine Citation:
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PMID: 17661841 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: The purpose of this article is to provide a systematic review of the available pharmacokinetic and clinical data on drug interactions between protease inhibitors (PIs) and acid-reducing agents, and their clinical relevance. METHODS: A literature search was performed using Medline and EMBASE, abstracts of the previous 2 years of major conferences were searched and the drug information service of the manufacturer of every currently available PI was contacted. All data were summarized, and verified by at least two authors. RESULTS: A total of 1231 references were identified, 22 of which were studies of pharmacokinetic interactions between PIs and acid-suppressive agents and a further 12 of which provided pharmacokinetic and/or clinical data. CONCLUSIONS: Many pharmacokinetic studies show a lack of a drug interaction between at least one acid-reducing agent and most PIs. Little clinical information is available, except on interactions between atazanavir and acid-reducing agents. This is probably a consequence of the complexity of the interaction. |
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Authors:
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L Béïque; P Giguère; C la Porte; J Angel |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: HIV medicine Volume: 8 ISSN: 1464-2662 ISO Abbreviation: HIV Med. Publication Date: 2007 Sep |
Date Detail:
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Created Date: 2007-07-30 Completed Date: 2007-12-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100897392 Medline TA: HIV Med Country: England |
Other Details:
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Languages: eng Pagination: 335-45 Citation Subset: IM |
Affiliation:
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Ottawa Health Research Institute, Ottawa, Ontario, Canada. lbeique@ottawahospital.on.ca |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antacids
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pharmacokinetics*,
therapeutic use Drug Interactions / physiology Female HIV Infections / blood*, metabolism Histamine Antagonists / pharmacokinetics*, therapeutic use Humans Male Protease Inhibitors / blood, pharmacokinetics* Proton Pump Inhibitors / therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Antacids; 0/Histamine Antagonists; 0/Protease Inhibitors; 0/Proton Pump Inhibitors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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