Document Detail

Interactions between n-3 and n-6 essential fatty acids (EFAs) in the regulation of cardiovascular disorders and inflammation.
MedLine Citation:
PMID:  1745654     Owner:  NLM     Status:  MEDLINE    
Much attention has recently been paid to the possible benefits of increasing the intake of eicosapentaenoic acid (EPA) by consuming fish oil. However, this can have adverse effects such as raising cholesterol levels in patients with hyperlipidaemia and causing a deterioration in glucose tolerance. High doses of EPA given to Westerners also lower levels of dihomogammalinolenic acid (DGLA), a substance with a wide range of desirable cardiovascular and antiinflammatory actions. This lowering of DGLA does not occur in Eskimos who consume large amounts of EPA, indicating that there may be differences in essential fatty acid metabolism between Westerners and Eskimos. Therapeutic strategies are required which raise both EPA and DGLA and which do not raise EPA at the cost of lowering DGLA.
D F Horrobin
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Prostaglandins, leukotrienes, and essential fatty acids     Volume:  44     ISSN:  0952-3278     ISO Abbreviation:  Prostaglandins Leukot. Essent. Fatty Acids     Publication Date:  1991 Oct 
Date Detail:
Created Date:  1992-01-15     Completed Date:  1992-01-15     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8802730     Medline TA:  Prostaglandins Leukot Essent Fatty Acids     Country:  SCOTLAND    
Other Details:
Languages:  eng     Pagination:  127-31     Citation Subset:  IM    
Efamol Research Institute, Kentville, Nova Scotia, Canada.
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MeSH Terms
8,11,14-Eicosatrienoic Acid / metabolism
Cardiovascular Diseases / prevention & control*
Cholesterol / metabolism
Dietary Fats, Unsaturated / administration & dosage
Drug Interactions
Eicosapentaenoic Acid / administration & dosage,  metabolism
Fatty Acids, Essential / administration & dosage*,  metabolism
Inflammation / prevention & control*
Reg. No./Substance:
0/Dietary Fats, Unsaturated; 0/Fatty Acids, Essential; 1553-41-9/Eicosapentaenoic Acid; 57-88-5/Cholesterol; 7324-41-6/8,11,14-Eicosatrienoic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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