Document Detail

Interactions between leptin and exendin-4, a glucagon-like peptide-1 agonist, in the regulation of food intake in the rat.
MedLine Citation:
PMID:  17622702     Owner:  NLM     Status:  MEDLINE    
Leptin interplays with other peptides to control feeding behaviour in humans and animals. Using exendin-4, an agonist of glucagon-like peptide-1, we investigated whether leptin modifies its effect on food intake in the rat. In the first series, exendin-4 alone (0.1, 2 or 10 microg per rat), leptin alone (0.1, 2, 10 or 100 microg per rat) or exendin-4 and leptin together (0.1 + 0.1, 2 + 2, 10 + 10, or 2 + 100 microg per rat, respectively) were injected once intraperitoneally. In the second series animals were injected either with exendin-4 (2 microg) alone, leptin (10 microg) alone, or leptin (10 microg) + exendin-4 (2 microg) daily for 5 subsequent days. At the lowest dose used, leptin and exendin-4 injected once together, but not separately, reduced significantly a 24-hour food intake. When used in higher doses, however, leptin did not change the exendin-4-dependent suppressory effect on food consumption. No significant differences in food intake were seen between rats treated repeatedly with exendin-4 only and animals injected with both drugs. Hence, leptin and exendin-4 may act additively to inhibit appetite when present in low concentrations while, at high leptin doses, this effect is abolished. The lack of synergistic effects of exendin-4 and high leptin concentrations on food intake may explain, at least in part, mechanisms responsible for leptin resistance in subjects with hyperleptinaemia.
E Bojanowska; A Nowak
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of physiology and pharmacology : an official journal of the Polish Physiological Society     Volume:  58     ISSN:  0867-5910     ISO Abbreviation:  J. Physiol. Pharmacol.     Publication Date:  2007 Jun 
Date Detail:
Created Date:  2007-07-11     Completed Date:  2007-07-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9114501     Medline TA:  J Physiol Pharmacol     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  349-60     Citation Subset:  IM    
Department of Behavioral Pathophysiology, Institute of General and Experimental Pathology, Medical University of Lodz, Poland.
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MeSH Terms
Appetite / drug effects
Dose-Response Relationship, Drug
Drinking / drug effects
Drug Synergism
Eating / drug effects*
Glucagon-Like Peptide 1 / agonists*
Leptin / pharmacology*
Peptides / pharmacology*
Rats, Wistar
Venoms / pharmacology*
Reg. No./Substance:
0/Leptin; 0/Peptides; 0/Venoms; 141732-76-5/exenatide; 89750-14-1/Glucagon-Like Peptide 1

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