| Interactions between leptin and exendin-4, a glucagon-like peptide-1 agonist, in the regulation of food intake in the rat. | |
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MedLine Citation:
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PMID: 17622702 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Leptin interplays with other peptides to control feeding behaviour in humans and animals. Using exendin-4, an agonist of glucagon-like peptide-1, we investigated whether leptin modifies its effect on food intake in the rat. In the first series, exendin-4 alone (0.1, 2 or 10 microg per rat), leptin alone (0.1, 2, 10 or 100 microg per rat) or exendin-4 and leptin together (0.1 + 0.1, 2 + 2, 10 + 10, or 2 + 100 microg per rat, respectively) were injected once intraperitoneally. In the second series animals were injected either with exendin-4 (2 microg) alone, leptin (10 microg) alone, or leptin (10 microg) + exendin-4 (2 microg) daily for 5 subsequent days. At the lowest dose used, leptin and exendin-4 injected once together, but not separately, reduced significantly a 24-hour food intake. When used in higher doses, however, leptin did not change the exendin-4-dependent suppressory effect on food consumption. No significant differences in food intake were seen between rats treated repeatedly with exendin-4 only and animals injected with both drugs. Hence, leptin and exendin-4 may act additively to inhibit appetite when present in low concentrations while, at high leptin doses, this effect is abolished. The lack of synergistic effects of exendin-4 and high leptin concentrations on food intake may explain, at least in part, mechanisms responsible for leptin resistance in subjects with hyperleptinaemia. |
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Authors:
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E Bojanowska; A Nowak |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of physiology and pharmacology : an official journal of the Polish Physiological Society Volume: 58 ISSN: 0867-5910 ISO Abbreviation: J. Physiol. Pharmacol. Publication Date: 2007 Jun |
Date Detail:
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Created Date: 2007-07-11 Completed Date: 2007-07-26 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9114501 Medline TA: J Physiol Pharmacol Country: Poland |
Other Details:
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Languages: eng Pagination: 349-60 Citation Subset: IM |
Affiliation:
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Department of Behavioral Pathophysiology, Institute of General and Experimental Pathology, Medical University of Lodz, Poland. ebojanowska@bg.umed.lodz.pl |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Appetite / drug effects Dose-Response Relationship, Drug Drinking / drug effects Drug Synergism Eating / drug effects* Glucagon-Like Peptide 1 / agonists* Leptin / pharmacology* Male Peptides / pharmacology* Rats Rats, Wistar Venoms / pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Leptin; 0/Peptides; 0/Venoms; 141732-76-5/exenatide; 89750-14-1/Glucagon-Like Peptide 1 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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