Document Detail


Interactions between intestinal microbiota and innate immune system in pediatric inflammatory bowel disease.
MedLine Citation:
PMID:  22955361     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Inflammatory bowel disease (IBD) is the result of an altered immune homeostasis within the intestinal mucosa against the gut microbiota, leading to chronic inflammation in genetically predisposed individuals. Under normal conditions, the immune system defends against pathogens and prevents the passage of excessive intestinal bacteria; regulatory pathways must maintain a low-grade, controlled inflammation in a healthy gut, but also induce a protective response against pathogens. The innate immune system is the first-line defense from microbes; dendritic cells, macrophages, and epithelial cells produce an initial, immediate response. The immune system constantly controls commensal bacteria and utilizes constitutive antimicrobial mechanisms to sustain immune homeostasis. The discovery that several genes linked to IBD modulate microbial recognition and innate immune pathways, such as nucleotide oligomerization domain 2 (Nod2), and genes that mediate autophagy (ie, ATG16L1, IRGM), has highlighted the critical role of host-microbe interactions in controlling intestinal immune homeostasis. Commensal microorganisms actively interact with the intestinal mucosa and influence the activity of the immune system as well as the amplitude of the immune response. In contrast, host factors can influence microbes, which in turn modulate disease susceptibility. In this paper, we focus on the mechanisms that mediate host-microbe interactions and how the disruption of this balance leads to chronic intestinal inflammation in IBD.
Authors:
Salvatore Cucchiara; Laura Stronati; Marina Aloi
Publication Detail:
Type:  Journal Article; Retracted Publication    
Journal Detail:
Title:  Journal of clinical gastroenterology     Volume:  46 Suppl     ISSN:  1539-2031     ISO Abbreviation:  J. Clin. Gastroenterol.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-09-07     Completed Date:  2013-01-18     Revised Date:  2014-07-22    
Medline Journal Info:
Nlm Unique ID:  7910017     Medline TA:  J Clin Gastroenterol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  S64-6     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Bacteria
Child
Genetic Predisposition to Disease
Humans
Immunity, Innate / immunology*
Inflammatory Bowel Diseases / genetics,  immunology*,  microbiology*
Intestinal Mucosa / immunology,  microbiology*
Intestines / immunology,  microbiology
Metagenome*
Comments/Corrections
Retraction In:
J Clin Gastroenterol. 2014 Jul;48(6):565   [PMID:  24922408 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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