Document Detail

Interactions between the extracellular matrix and inflammation during viral myocarditis.
MedLine Citation:
PMID:  21907443     Owner:  NLM     Status:  Publisher    
Viral myocarditis is a life-threatening disease characterized by severe cardiac inflammation that can result in heart failure or sudden cardiac death in previously healthy adults. In a subset of patients, it may result in the development of dilated cardiomyopathy due to the chronic inflammatory process. Despite its clinical need, specific treatments for myocarditis are currently not available. The extracellular matrix (ECM) under normal conditions, functions to maintain the mechanical and structural integrity of the heart but can adapt under pathological circumstances to preserve cardiac function. Recent studies have revealed a crucial role of the ECM in the reparative process after cardiac insult, not only as a key component in cardiac remodeling but also as a regulator of the inflammatory process. Increasing our understanding of the impact the ECM has in the disease pathogenesis and progression of viral myocarditis, might lead to much needed therapeutic interventions. In this review we will describe the pathology of viral myocarditis and illustrate the interplay between inflammation and the ECM in general terms, and during viral myocarditis.
Anna-Pia Papageorgiou; Stephane Heymans
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-7-18
Journal Detail:
Title:  Immunobiology     Volume:  -     ISSN:  1878-3279     ISO Abbreviation:  -     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-9-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8002742     Medline TA:  Immunobiology     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Elsevier GmbH. All rights reserved.
Centre for Heart Failure Research, CARIM, University of Maastricht, Netherlands.
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