Document Detail


Interactions between ethanol and pantothenic acid on tremor and behavior in squirrel monkeys.
MedLine Citation:
PMID:  1556862     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Ethanol consumption alters the levels and distribution of pantothenic acid and its metabolic products, an effect that can be counteracted by preloading with pantothenic acid. Ethanol also produces significant disturbances in motor function and has a potent tremorolytic activity when administered acutely. To investigate the interaction of pantothenic acid and ethanol, the two substances were administered alone and in combination to three squirrel monkeys trained to perform a response-initiated positioning task that enabled the detection of tremor. Tremor was evaluated using spectral analytical techniques. Ethanol at 1.0 gm/kg produced a tenfold reduction in tremor over control sessions while pantothenic acid alone had no effect on tremor. Pantothenic acid (200 mg/kg, IP or IV) administered before ethanol intubation completely counteracted the tremor-reducing action of ethanol in two monkeys and partially counteracted it in a third. The interaction between pantothenic acid and ethanol was limited to these motor effects; the rate-reducing effect of ethanol was unaffected by pantothenic acid.
Authors:
M C Newland; L Rivera-Calimlim; B Weiss
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of studies on alcohol     Volume:  53     ISSN:  0096-882X     ISO Abbreviation:  J. Stud. Alcohol     Publication Date:  1992 Jan 
Date Detail:
Created Date:  1992-05-04     Completed Date:  1992-05-04     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7503813     Medline TA:  J Stud Alcohol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  80-5     Citation Subset:  IM    
Affiliation:
Department of Psychology, Auburn University, Alabama 36849.
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MeSH Terms
Descriptor/Qualifier:
Animals
Dose-Response Relationship, Drug
Ethanol / pharmacology*
Female
Nervous System / drug effects,  physiopathology
Oxotremorine
Pantothenic Acid / pharmacology*
Psychomotor Performance / drug effects*,  physiology
Saimiri
Tremor / chemically induced,  physiopathology*
Grant Support
ID/Acronym/Agency:
AA05188/AA/NIAAA NIH HHS; ES10247/ES/NIEHS NIH HHS; ES10248/ES/NIEHS NIH HHS
Chemical
Reg. No./Substance:
64-17-5/Ethanol; 70-22-4/Oxotremorine; 79-83-4/Pantothenic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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