| Interactions between coagulation and complement-their role in inflammation. | |
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MedLine Citation:
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PMID: 21811895 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The parallel expression of activation products of the coagulation, fibrinolysis, and complement systems has long been observed in both clinical and experimental settings. Several interconnections between the individual components of these cascades have also been described, and the list of shared regulators is expanding. The co-existence and interplay of hemostatic and inflammatory mediators in the same microenvironment typically ensures a successful host immune defense in compromised barrier settings. However, dysregulation of the cascade activities or functions of inhibitors in one or both systems can result in clinical manifestations of disease, such as sepsis, systemic lupus erythematosus, or ischemia-reperfusion injury, with critical thrombotic and/or inflammatory complications. An appreciation of the precise relationship between complement activation and thrombosis may facilitate the development of novel therapeutics, as well as improve the clinical management of patients with thrombotic conditions that are characterized by complement-associated inflammatory responses. |
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Authors:
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Katerina Oikonomopoulou; Daniel Ricklin; Peter A Ward; John D Lambris |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-8-3 |
Journal Detail:
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Title: Seminars in immunopathology Volume: - ISSN: 1863-2300 ISO Abbreviation: - Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-8-3 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101308769 Medline TA: Semin Immunopathol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Pathology & Laboratory Medicine, School of Medicine, University of Pennsylvania, 401 Stellar Chance Laboratories, 422 Curie Boulevard, Philadelphia, PA, 19104-6100, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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