Document Detail


Interactions between brainstem respiratory neurons.
MedLine Citation:
PMID:  7250384     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Interactions between brainstem respiratory neurons underlie respiratory rhythmogenesis. Several techniques to study these interactions are discussed. Cross-correlation analysis of the firing patterns of pairs of respiratory neurons revealed a high probability of interaction and/or shared inputs between neurons that are immediate neighbors, and the lack and ubiquitous connections between neurons located in different regions. Neuroanatomical studies demonstrated a previously unobserved brainstem projection to the ventrolateral nucleus of tractus solitarius, an important brainstem respiratory-related structure, from a small cluster of neurons in the contralateral ventrolateral medulla several millimeters rostral to the obex; subsequent recordings have shown these neurons to have expiratory firing patterns. Modeling studies suggested that neurons hypothesized to produce inspiratory phase termination should begin firing late in the inspiratory phase and should be excited by lung inflation. Subsequent extracellular recordings have shown that neurons with these properties constitute a significant fraction of neurons in the region of te ventrolateral nucleus of tractus solitarius. The results of these studies indicate that rhythmogenesis results from highly specific interactions between limited subpopulations of respiratory neurons.
Authors:
J L Feldman
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Federation proceedings     Volume:  40     ISSN:  0014-9446     ISO Abbreviation:  Fed. Proc.     Publication Date:  1981 Jul 
Date Detail:
Created Date:  1981-09-22     Completed Date:  1981-09-22     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0372771     Medline TA:  Fed Proc     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2384-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Brain Stem / anatomy & histology*
Diaphragm / innervation
Humans
Models, Neurological
Neural Conduction
Neural Pathways
Neurons / cytology,  physiology*
Respiratory Center / cytology,  physiology*
Grant Support
ID/Acronym/Agency:
HL-00554/HL/NHLBI NIH HHS; HL-23820/HL/NHLBI NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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