Document Detail

Interactions between bacterial pathogens and mitochondrial cell death pathways.
MedLine Citation:
PMID:  20818415     Owner:  NLM     Status:  MEDLINE    
The modulation of host cell death pathways by bacteria has been recognized as a major pathogenicity mechanism. Among other strategies, bacterial pathogens can hijack the cell death machinery of host cells by influencing the signalling pathways that converge on the mitochondria. In particular, many bacterial proteins have evolved to interact in a highly specific manner with host mitochondria, thereby modulating the decision between cell life and death. In this Review, we explore the intimate interactions between bacterial pathogens and mitochondrial cell death pathways.
Thomas Rudel; Oliver Kepp; Vera Kozjak-Pavlovic
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Publication Detail:
Type:  Journal Article; Review     Date:  2010-09-06
Journal Detail:
Title:  Nature reviews. Microbiology     Volume:  8     ISSN:  1740-1534     ISO Abbreviation:  Nat. Rev. Microbiol.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-09-16     Completed Date:  2010-09-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101190261     Medline TA:  Nat Rev Microbiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  693-705     Citation Subset:  IM    
Lehrstuhl für Mikrobiologie, Biozentrum der Universität Würzburg, Germany.
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MeSH Terms
Apoptosis / physiology
Bacteria* / metabolism,  pathogenicity
Bacterial Proteins / metabolism
Cell Death / physiology*
Host-Pathogen Interactions / physiology*
Mitochondria / microbiology*
Signal Transduction / physiology*
Reg. No./Substance:
0/Bacterial Proteins

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