Document Detail


Interactions between arterial pressure and sodium excretion.
MedLine Citation:
PMID:  8834163     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Recent developments have led to renewed interest in the mechanisms that mediate the changes in sodium excretion in response to changes in arterial pressure, a phenomenon termed pressure-natriuresis. Pressure-natriuresis occurs in the absence of changes in filtered load and thus, the changes in sodium excretion are caused by changes in net tubular sodium reabsorption. Both proximal and distal nephron segments have been implicated as the sites of altered reabsorption. The specific mechanism responsible for pressure-natriuresis remains unresolved. One proposal suggests that changes in renal interstitial fluid pressure which may be due, in part, to a less efficient autoregulation of the renal medullary circulation than of the cortex, alter sodium reabsorption. Alternatively, recent studies indicate that increases in arterial pressure increase endothelial nitric oxide formation which inhibits sodium reabsorption via direct effects on the tubules as well as hemodynamically mediated effects.
Authors:
L G Navar; D S Majid
Related Documents :
6723013 - The effects of familial relationships, age, body weight, and diet on blood pressure and...
8072293 - Effects of simulated potassium blockade on the dynamics of triggered cardiac activity.
627133 - Hemodynamic and respiratory effects of morphine and butorphanol.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Current opinion in nephrology and hypertension     Volume:  5     ISSN:  1062-4821     ISO Abbreviation:  Curr. Opin. Nephrol. Hypertens.     Publication Date:  1996 Jan 
Date Detail:
Created Date:  1996-12-03     Completed Date:  1996-12-03     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9303753     Medline TA:  Curr Opin Nephrol Hypertens     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  64-71     Citation Subset:  IM    
Affiliation:
Department of Physiology, Tulane University School of Medicine, New Orleans, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Blood Pressure
Humans
Kidney / blood supply*,  metabolism
Natriuresis / physiology*
Sodium / metabolism*
Grant Support
ID/Acronym/Agency:
HL 18426/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
7440-23-5/Sodium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Control of the renal microcirculation: cellular and integrative perspectives.
Next Document:  The sympathetic nervous system in hypertension and renal disease.