| Interactions between antifungal and antiretroviral agents. | |
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MedLine Citation:
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PMID: 20345324 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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IMPORTANCE OF THE FIELD: Since the advent of combination antiretroviral therapy, the incidence of opportunistic infections has declined and the life expectancy of HIV-infected people has significantly increased. However, opportunistic infections, including fungal diseases, remain a leading cause of hospitalizations and mortality in HIV-infected people. With the availability of several new antiretroviral and antifungal agents, drug-drug interactions emerge as a potential safety concern. AREAS COVERED IN THIS REVIEW: Relevant literature was identified using a Medline search of articles published up to March 2010 and a review of conference abstracts. Search terms included HIV, antifungal agents and drug interactions. Original papers and relevant citations were considered for this review. WHAT THE READER WILL GAIN: Readers will gain an understanding of the pharmacokinetic properties of antiretroviral and antifungal agents, and insight into significant drug-drug interactions which may require dosage adjustments or a change in therapy. TAKE HOME MESSAGE: Azole antifungal drugs, with the exception of fluconazole, pose the greatest risk of two-way interactions with antiretroviral drugs through CYP450 enzymes effects. Limited studies suggest the risk of interactions between antiretroviral drugs and echinocandins is much lower. The combination of tenofovir and amphotericin B should be used with caution and close monitoring of renal function is required. |
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Authors:
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Christine A Hughes; Michelle Foisy; Alice Tseng |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Expert opinion on drug safety Volume: 9 ISSN: 1744-764X ISO Abbreviation: Expert Opin Drug Saf Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-08-20 Completed Date: 2011-01-24 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101163027 Medline TA: Expert Opin Drug Saf Country: England |
Other Details:
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Languages: eng Pagination: 723-42 Citation Subset: IM |
Affiliation:
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University of Alberta, Faculty of Pharmacy & Pharmaceutical Sciences, 3126 Dent/Pharm Centre, Edmonton, AB, T6G 2N8 Canada. chughes@pharmacy.ualberta.ca |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amphotericin B
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adverse effects,
pharmacokinetics Anti-Retroviral Agents / adverse effects, pharmacokinetics* Antifungal Agents / adverse effects, pharmacokinetics* Azoles / adverse effects, pharmacokinetics Biotransformation Cytochrome P-450 Enzyme System / metabolism Drug Interactions Echinocandins / adverse effects, pharmacokinetics HIV Infections / drug therapy Humans Kidney / metabolism Microsomes, Liver / metabolism Mycoses / drug therapy |
| Chemical | |
Reg. No./Substance:
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0/Anti-Retroviral Agents; 0/Antifungal Agents; 0/Azoles; 0/Echinocandins; 1397-89-3/Amphotericin B; 9035-51-2/Cytochrome P-450 Enzyme System |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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