| Interactions between age and apoE genotype on fasting and postprandial triglycerides levels. | |
| | |
MedLine Citation:
|
PMID: 20643407 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
|
OBJECTIVE: The influences of genetic determinants on the magnitude of postprandial lipaemia are presently unclear. Here the impact of the common apolipoprotein (apo)E epsilon mutation on the postprandial triglyceride (TG) response is determined, along with an assessment of genotype penetrance according to age, body mass index and gender. METHODS AND RESULTS: Healthy adults (n=251) underwent a postprandial investigation, in which blood samples were taken at regular intervals after a test breakfast (0 min, 49 g fat) and lunch (330 min, 29 g fat) until 480 min after the test breakfast. There was a significant impact of apoE genotype on fasting total cholesterol (TC), (P=0.027), LDL-cholesterol (LDL-C), (P=0.008), and %LDL(3) (P=0.001), with higher and lower levels in the E4 and E2 carriers respectively relative to the E3/E3 genotype. Reflective of a higher fasting TG (P=0.001), a significantly higher area under the curve for the postprandial TG response (TG AUC) was evident in the E4 carriers relative to the E3/E3 group (P=0.038). In the group as a whole, a significant age×genotype interaction was observed for fasting TC (P=0.021). In the participants>50 years there was a significant impact of genotype on TC (P=0.005), LDL-C (P=0.001) and TAG AUC (P=0.028). CONCLUSIONS: It is possible that an exaggerated postprandial lipaemia contributes to the increased coronary heart disease risk associated with carriers of the E4 allele; an effect which is more evident in older adults. |
| | |
Authors:
|
Andrew L Carvalho-Wells; Kim G Jackson; Rosalynn Gill; Estibaliz Olano-Martin; Julie A Lovegrove; Christine M Williams; Anne M Minihane |
Related Documents
:
|
190607 - Effect of gemfibrozil on lipoprotein concentrations in different types of hyperlipoprot... 6337937 - Effect of sucrose diet on insulin secretion in vivo and in vitro and on triglyceride st... 1015357 - Removal of exogenous triglycerides in subjects with massive obesity before and after je... 6670057 - Extent of retention of 2-monoglyceride backbone of diet fat in alcohol-induced fatty li... 16177197 - Supplementing copper at the upper level of the adult dietary recommended intake induces... 12619807 - Administration of triiodothyronine and dopamine to broiler chicks increases growth, fee... |
Publication Detail:
|
Type: Journal Article Date: 2010-06-30 |
Journal Detail:
|
Title: Atherosclerosis Volume: 212 ISSN: 1879-1484 ISO Abbreviation: Atherosclerosis Publication Date: 2010 Oct |
Date Detail:
|
Created Date: 2010-10-11 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0242543 Medline TA: Atherosclerosis Country: Ireland |
Other Details:
|
Languages: eng Pagination: 481-7 Citation Subset: IM |
Copyright Information:
|
Copyright © 2010 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
|
Department of Food and Nutritional Sciences and Institute of Cardiovascular and Metabolic Research, University of Reading, Reading RG6 6AP, UK. a.l.wells@reading.ac.uk |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Carotid, aortic arch and coronary calcification are related to history of stroke: the Rotterdam Stud...
Next Document: Transcriptional factor prolactin regulatory element-binding protein-mediated gene transcription of A...