Document Detail

Interactions between acidic proteins and crystals: stereochemical requirements in biomineralization.
MedLine Citation:
PMID:  3858868     Owner:  NLM     Status:  MEDLINE    
Acidic matrix macromolecules are intimately involved in biological crystal growth. In vitro experiments, in which crystals of calcium dicarboxylate salts were grown in the presence of aspartic acid-rich proteins, revealed a stereochemical property common to all the interacting faces. Calcite crystals are nucleated on stereochemically analogous faces when proteins are adsorbed onto a rigid substrate. The importance of this property in biomineralization is discussed.
L Addadi; S Weiner
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Proceedings of the National Academy of Sciences of the United States of America     Volume:  82     ISSN:  0027-8424     ISO Abbreviation:  Proc. Natl. Acad. Sci. U.S.A.     Publication Date:  1985 Jun 
Date Detail:
Created Date:  1985-07-25     Completed Date:  1985-07-25     Revised Date:  2010-09-13    
Medline Journal Info:
Nlm Unique ID:  7505876     Medline TA:  Proc Natl Acad Sci U S A     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  4110-4     Citation Subset:  IM; S    
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MeSH Terms
Aspartic Acid
Bone Matrix / metabolism
Calcification, Physiologic*
Calcium / metabolism
Dicarboxylic Acids
Extracellular Matrix / metabolism*
Isoelectric Point
Models, Biological
Reg. No./Substance:
0/Dicarboxylic Acids; 56-84-8/Aspartic Acid; 7440-70-2/Calcium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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