| Interactions between Verapamil and Digoxin in Langendorff-Perfused Rat Hearts: The Role of Inhibition of P-glycoprotein in the Heart. | |
| | |
MedLine Citation:
|
PMID: 20412466 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
P-glycoprotein (P-gp) is expressed in tumour cells as well as normal tissues including heart. Modulation of P-gp transport in vivo may lead to increased drug penetrance to tissues with resulting increases in toxicity. We aimed to investigate the effects of P-gp on the isolated heart by digoxin infusion in the absence and presence of verapamil. The study was performed in Langendorff isolated perfused rat hearts. After a 20 min. stabilisation period with Tyrode Buffer, digoxin (125 mug/5 mL) was infused for 10 min. in the control group (n = 7). The same dose of digoxin was infused during perfusion with verapamil (1 nm) containing Tyrode Buffer (n = 8) in the study group. Outflow concentration and cardiac parameters of digoxin were measured at frequent intervals for 40 min. AUEC((0-40 min)) for left ventricular developed pressure was significantly increased in the presence of verapamil (4260 +/- 39.37 mmHg min versus 4607 +/- 98.09 mmHg min; 95% CI -587.7 to -105.8; p = 0.0083). The significant increases in left ventricular developed pressure were at 20, 25, 30, 35 and 40 min. AUC((0-40 min)) value for outflow digoxin concentration-time curve was significantly lower in the presence of verapamil. Verapamil increased the positive inotropic effect of digoxin, probably through the inhibition of P-gp, which effluxes digoxin out of cardiac cells. |
| | |
Authors:
|
Mualla Aylin Arici; Emrah Kilinc; Omer Demir; Mehmet Ates; Alaattin Yesilyurt; Ayse Gelal |
Related Documents
:
|
10633256 - A network thermodynamic model of kidney perfusion with a cryoprotective agent. 15687106 - Beta-agonist stimulation produces changes in cardiac ampk and coronary lumen lpl only d... 7488786 - New technique for retrograde cerebral perfusion during arch aneurysm repair. 7852036 - Evaluation of calcitonin-gene related peptide on haemodynamics of isolated perfused rat... 11140426 - Improving the accuracy of pulmonary artery catheter measurements. 7067596 - Pathogenesis of raised cerebrospinal fluid pressure. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2010-4-20 |
Journal Detail:
|
Title: Basic & clinical pharmacology & toxicology Volume: - ISSN: 1742-7843 ISO Abbreviation: - Publication Date: 2010 Apr |
Date Detail:
|
Created Date: 2010-4-23 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101208422 Medline TA: Basic Clin Pharmacol Toxicol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Dokuz Eylul University, School of Medicine, Department of Pharmacology, Izmir, Turkey. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Lignophenols decrease oleate-induced apolipoprotein-B secretion in HepG2 cells.
Next Document: Perioperative outcome and long-term mortality for heart failure patients undergoing intermediate- an...