Document Detail


Interactions between Δ(9)-tetrahydrocannabinol and heroin: self-administration in rhesus monkeys.
MedLine Citation:
PMID:  23044830     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The cannabinoid receptor agonist Δ(9)-tetrahydrocannabinol (THC) enhances the antinociceptive effects of µ-opioid receptor agonists, raising the possibility of using a combination of THC and opioids for treating pain. This study examined the effects of noncontingent and contingent administration of THC on intravenous heroin self-administration in rhesus monkeys. Self-administration of different unit doses of heroin (0.0001-0.1 mg/kg/infusion) generated a typical inverted U-shaped dose-response curve. In one experiment (n=4), noncontingent THC (0.1-1.0 mg/kg) dose dependently shifted the heroin dose-response curve downward in three monkeys and slightly leftward in one monkey. In a second experiment (n=4), monkeys could self-administer THC alone (0.0032-0.032 mg/kg/infusion), heroin alone, or a mixture of THC and heroin. THC alone did not maintain responding above that obtained with saline; however, increasing the THC dose with heroin dose dependently decreased the number of infusions received and the rate of responding, as compared with data that were obtained with heroin alone. These results indicate that THC does not significantly enhance the positive reinforcing effects of heroin, further supporting the view that combining cannabinoid and opioid receptor agonists (e.g. for treating pain) does not increase, and might decrease, the abuse liability of individual drugs.
Authors:
Jun-Xu Li; Wouter Koek; Charles P France
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Behavioural pharmacology     Volume:  23     ISSN:  1473-5849     ISO Abbreviation:  Behav Pharmacol     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-11-08     Completed Date:  2013-05-01     Revised Date:  2014-02-14    
Medline Journal Info:
Nlm Unique ID:  9013016     Medline TA:  Behav Pharmacol     Country:  England    
Other Details:
Languages:  eng     Pagination:  754-61     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Cannabinoid Receptor Agonists / administration & dosage,  pharmacology*
Dose-Response Relationship, Drug
Dronabinol / administration & dosage,  pharmacology*
Drug Interactions
Female
Heroin / administration & dosage,  pharmacology*
Macaca mulatta
Male
Reinforcement Schedule*
Self Administration
Grant Support
ID/Acronym/Agency:
K05 DA017918/DA/NIDA NIH HHS; K05DA17918/DA/NIDA NIH HHS; R01 DA005018/DA/NIDA NIH HHS; R01DA05018/DA/NIDA NIH HHS
Chemical
Reg. No./Substance:
0/Cannabinoid Receptor Agonists; 70D95007SX/Heroin; 7J8897W37S/Dronabinol
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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