Document Detail

Interactions of ascorbic acid supplementation and bleomycin instillation on murine lung connective tissue metabolism.
MedLine Citation:
PMID:  6205840     Owner:  NLM     Status:  MEDLINE    
The effects of ascorbic acid supplementation on the pulmonary toxicity induced by bleomycin were examined. Swiss-Webster mice were fed an ascorbate-free diet supplemented with ascorbic acid at 0%, 0.2%, or 1.0% of the diet for 2 weeks. Bleomycin (0.15 units) was instilled intratracheally and the mice were killed 1 week later. Bleomycin caused pulmonary inflammation and edema as noted by the increases in lung wet weight and lung wet-weight-to-dry-weight ratios. The activity of prolyl hydroxylase was increased 1.4-fold to 1.6-fold in response to bleomycin, but only minor increases were observed in the collagen and elastin content of the lung. Prior dietary ascorbic acid supplementation did not reverse the effects induced by bleomycin. Interestingly, each dietary level of supplemental ascorbic acid resulted in a slight increase in the elastin and collagen content of the lung in comparison with lungs from mice consuming no ascorbic acid in their diet. The data suggest that high levels of ascorbic acid supplementation may aggravate the response to bleomycin.
M A Dubick; J A Last; C E Cross; R B Rucker
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Drug-nutrient interactions     Volume:  2     ISSN:  0272-3530     ISO Abbreviation:  Drug Nutr Interact     Publication Date:  1983  
Date Detail:
Created Date:  1984-10-03     Completed Date:  1984-10-03     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8307198     Medline TA:  Drug Nutr Interact     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  105-15     Citation Subset:  IM    
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MeSH Terms
Ascorbic Acid / pharmacology*
Bleomycin / pharmacology*
Body Weight / drug effects
Collagen / metabolism
Connective Tissue / drug effects*,  metabolism
Desmosine / metabolism
Drug Interactions
Elastin / metabolism
Hydroxyproline / metabolism
Lung / drug effects*,  metabolism
Organ Size / drug effects
Procollagen-Proline Dioxygenase / metabolism
Grant Support
Reg. No./Substance:
11003-57-9/Desmosine; 11056-06-7/Bleomycin; 50-81-7/Ascorbic Acid; 51-35-4/Hydroxyproline; 9007-34-5/Collagen; 9007-58-3/Elastin; EC Dioxygenase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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