Document Detail


Interactions of anticoagulant insoluble modified polystyrene resins with plasmatic proteins.
MedLine Citation:
PMID:  7157229     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In previous papers, we have described the preparation and heparin-like properties of insoluble modified polystyrene resins. We now report results about the interactions of several coagulation factors with some of these materials. Most of the non-activated factors are neither adsorbed nor modified, except factor V and prekallikrein. In contrast thrombin, antithrombin III and factor Xa adsorb on the surface of such insoluble polymers. Thrombin can be desorbed by addition of a polycationic compound. The inactivation of thrombin or factor Xa by antithrombin is catalysed by the presence in the mixture of these insoluble materials as it is with soluble heparin. The initial velocity of these reactions is second order for both types of catalysis-homogeneous or heterogeneous - as previously reported for soluble heparin. In the case of these insoluble materials, the inhibition of protease by antiprotease seems to be accelerated when complexes are formed between the polymer and the proteins.
Authors:
C Fougnot; M Jozefowicz; L Bara; M Samama
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Thrombosis research     Volume:  28     ISSN:  0049-3848     ISO Abbreviation:  Thromb. Res.     Publication Date:  1982 Oct 
Date Detail:
Created Date:  1983-03-11     Completed Date:  1983-03-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0326377     Medline TA:  Thromb Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  37-46     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adsorption
Anticoagulants*
Blood Coagulation Factors*
Humans
Kinetics
Polystyrenes / pharmacology*
Resins, Synthetic / pharmacology*
Chemical
Reg. No./Substance:
0/Anticoagulants; 0/Blood Coagulation Factors; 0/Polystyrenes; 0/Resins, Synthetic

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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