Document Detail


Interactions of aflatoxin and the antioxidant butylated hydroxytoluene in two-week-old chicks.
MedLine Citation:
PMID:  3195047     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Two-week dietary administration of 2500 ppb aflatoxin was sufficient to cause a decrease in bursal weights and a reduction in the number of splenic leukocytes in chicks. No significant effects on weight gain or feed efficiency were evident. The chicks also had elevated heterophil-to-lymphocyte ratios, suggesting a heightened reaction to stress. This effect could be blocked by dietary administration of the antioxidant butylated hydroxytoluene (BHT) at a concentration eight-fold over that normally present to preserve control feed. The BHT treatment increased the activities of the enzymes glutathione-S-transferase, aniline hydroxylase and O-demethylase, which metabolize aflatoxins in the liver.
Authors:
M Ehrich; M Acha; C Larsen
Related Documents :
1144927 - The effect of the administration of solanum malacoxylon on the chick.
11110997 - Time structure of behavioral patterns related to feed pecking in chicks.
16854637 - Experimental ochratoxicosis in broiler chickens.
6639927 - N tau-methyl histidine excretion by poultry: not all species excrete n tau-methyl histi...
2379787 - Serum lipids and gallstones: a case-control study.
24735567 - Factors related to sustained use of a free mobile app for dietary self-monitoring with ...
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Veterinary research communications     Volume:  12     ISSN:  0165-7380     ISO Abbreviation:  Vet. Res. Commun.     Publication Date:  1988  
Date Detail:
Created Date:  1989-01-06     Completed Date:  1989-01-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8100520     Medline TA:  Vet Res Commun     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  329-33     Citation Subset:  IM    
Affiliation:
Virginia-Maryland Regional College of Veterinary Medicine, Blacksburg 24061.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Aflatoxins / toxicity*
Aniline Hydroxylase / metabolism
Animals
Animals, Newborn
Body Weight / drug effects
Bursa of Fabricius / drug effects
Butylated Hydroxytoluene / administration & dosage,  pharmacology*
Chickens / physiology*
Drug Interactions
Glutathione Transferase / metabolism
Leukocyte Count
Liver / enzymology
Organ Size / drug effects
Oxidoreductases, O-Demethylating / metabolism
Weight Gain / drug effects
Chemical
Reg. No./Substance:
0/Aflatoxins; 128-37-0/Butylated Hydroxytoluene; EC 1.-/Oxidoreductases, O-Demethylating; EC 1.14.14.-/Aniline Hydroxylase; EC 2.5.1.18/Glutathione Transferase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  The ant, Pachycondyla sennaarensis (Mayr) as an intermediate host for the poultry cestode, Raillieti...
Next Document:  Field evaluation of an experimental albendazole pulse release bolus in the control of parasitic gast...