Document Detail

Interactions of aflatoxin and the antioxidant butylated hydroxytoluene in two-week-old chicks.
MedLine Citation:
PMID:  3195047     Owner:  NLM     Status:  MEDLINE    
Two-week dietary administration of 2500 ppb aflatoxin was sufficient to cause a decrease in bursal weights and a reduction in the number of splenic leukocytes in chicks. No significant effects on weight gain or feed efficiency were evident. The chicks also had elevated heterophil-to-lymphocyte ratios, suggesting a heightened reaction to stress. This effect could be blocked by dietary administration of the antioxidant butylated hydroxytoluene (BHT) at a concentration eight-fold over that normally present to preserve control feed. The BHT treatment increased the activities of the enzymes glutathione-S-transferase, aniline hydroxylase and O-demethylase, which metabolize aflatoxins in the liver.
M Ehrich; M Acha; C Larsen
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Veterinary research communications     Volume:  12     ISSN:  0165-7380     ISO Abbreviation:  Vet. Res. Commun.     Publication Date:  1988  
Date Detail:
Created Date:  1989-01-06     Completed Date:  1989-01-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8100520     Medline TA:  Vet Res Commun     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  329-33     Citation Subset:  IM    
Virginia-Maryland Regional College of Veterinary Medicine, Blacksburg 24061.
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MeSH Terms
Administration, Oral
Aflatoxins / toxicity*
Aniline Hydroxylase / metabolism
Animals, Newborn
Body Weight / drug effects
Bursa of Fabricius / drug effects
Butylated Hydroxytoluene / administration & dosage,  pharmacology*
Chickens / physiology*
Drug Interactions
Glutathione Transferase / metabolism
Leukocyte Count
Liver / enzymology
Organ Size / drug effects
Oxidoreductases, O-Demethylating / metabolism
Weight Gain / drug effects
Reg. No./Substance:
0/Aflatoxins; 128-37-0/Butylated Hydroxytoluene; EC 1.-/Oxidoreductases, O-Demethylating; EC 1.14.14.-/Aniline Hydroxylase; EC Transferase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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