| Interactions of acetylcholine and epinephrine on the dynamics of insulin release in vitro. | |
| | |
MedLine Citation:
|
PMID: 932207 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
An in vitro system for perifusion of rat pancreatic islets has been utilized to define the effects of epinephrine on acetylcholine-induced insulin release over varying concentrations of the two agents. Perifusion of islets with epinephrine before challenge with acetycholine produced marked enhancement of both phases of cholinergically induced insulin release; enhancement of the first phase being more marked with increase in acetylcholine concentration and the converse being observed with the second phase. Perifusion of islets with epinephrine during stimulation with acetylcholine produced inhibition of insulin release, an effect dependent upon the concentration of epinephrine and of acetylcholine. There was an order of difference in the acetycholine concentration needed to overcome significant epinephrine-mediated inhibition of the first phase of insulin release (5 X 10(-4) mug/ml) and that needed to overcome inhibition of the second phase (5 X 10(-3) mug/ml). Comparison of the effects of various concentrations of epinephrine on glucose- and acetyl-choline-induced insulin release revealed that epinephrine was a less potent inhibitor of the first phase of acetylcholine-induced insulin release than of the first phase of glucose-induced insulin release. These data provide some insight into the potential interactions between cholinergic and adrenergic autonomic systems in modifying insulin release. |
| | |
Authors:
|
I M Burr; A E Slonim; R Sharp |
Related Documents
:
|
220017 - Somatostatin secretion from monolayer cultures of neonatal rat pancreas. 8472627 - Mechanism of insulin secretion by midaglizole. 9972287 - Effect of carbohydrates upon insulin secretion in bufo arenarum (amphibia:bufonidae). 825207 - The role of insulin in the glucostatic control of food intake. 16678327 - Ppar-gamma2 pro12ala polymorphism is associated with weight gain in women with gestatio... 16448577 - Effect of insulin on small intestinal transit in normal mice is independent of blood gl... |
Publication Detail:
|
Type: In Vitro; Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: The Journal of clinical investigation Volume: 58 ISSN: 0021-9738 ISO Abbreviation: J. Clin. Invest. Publication Date: 1976 Jul |
Date Detail:
|
Created Date: 1976-08-23 Completed Date: 1976-08-23 Revised Date: 2009-11-18 |
Medline Journal Info:
|
Nlm Unique ID: 7802877 Medline TA: J Clin Invest Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 230-9 Citation Subset: AIM; IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Acetylcholine
/
administration & dosage,
pharmacology* Animals Drug Interactions Epinephrine / pharmacology* Female Glucose / diagnostic use Insulin / metabolism* Male Rats |
| Chemical | |
Reg. No./Substance:
|
11061-68-0/Insulin; 50-99-7/Glucose; 51-43-4/Epinephrine; 51-84-3/Acetylcholine |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Physical chemistry of the lipids of human atherosclerotic lesions. Demonstration of a lesion interme...
Next Document: Lymphokine stimulation of collagen accumulation.