| Interactions of Listeria monocytogenes with the Autophagy System of Host Cells. | |
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MedLine Citation:
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PMID: 22244576 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Macrophages are immune cells that participate in the host defense against bacterial pathogens. These cells mediate bacterial clearance by internalizing bacteria into a phagosome, which ultimately fuses with lysosomes to kill bacteria. One bacterial strategy to evade killing in the phagosome is to escape from this compartment prior to lysosomal fusion. Listeria monocytogenes is a classic example of a "cytosol-adapted pathogen" in that it can rapidly escape from the phagosome in macrophages (and other cell types) and replicate rapidly in the cytosol. Phagosome escape also enables cell-to-cell spread by the bacteria through a bacterial driven actin-based motility mechanism. How the bacteria escape the phagosome and evade host cellular defenses, including autophagy, will be discussed in this review. We also discuss an underappreciated population of L. monocytogenes that can replicate in macrophage vacuoles and how these may be important for the establishment of chronic infections. |
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Authors:
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Grace Y Lam; Mark A Czuczman; Darren E Higgins; John H Brumell |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Advances in immunology Volume: 113 ISSN: 1557-8445 ISO Abbreviation: Adv. Immunol. Publication Date: 2012 |
Date Detail:
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Created Date: 2012-01-16 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370425 Medline TA: Adv Immunol Country: United States |
Other Details:
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Languages: eng Pagination: 7-18 Citation Subset: IM |
Copyright Information:
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Copyright © 2012 Elsevier Inc. All rights reserved. |
Affiliation:
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Cell Biology Program, Hospital for Sick Children, Toronto, Ontario, Canada; Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada. |
Export Citation:
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