Document Detail

Interactions of HLA-DRB4 and CTLA-4 genes influence thyroid function in Hashimoto's thyroiditis in Japanese population.
MedLine Citation:
PMID:  15055474     Owner:  NLM     Status:  MEDLINE    
Hashimoto's thyroiditis (HT) is an autoimmune disease of the thyroid gland, and like many other autoimmune diseases, it is associated with the HLA and CTLA-4 gene. We have examined the distribution of the HLA DRB4*0101 allele and a CTLA-4 exon 1 A/G polymorphism in Japanese HT patients and controls and investigated possible interactions of these genes with thyroid function. Seventy Japanese HT patients and 105 controls were included in this study. HT was diagnosed on the basis of positivity for thyroid peroxidase (TPO) autoantibodies and the presence of a palpable diffuse goiter. Genotyping was performed by polymerase chain reaction (PCR)-based methods. CTLA-4-GG or -AG was more prevalent in the patients, and the odds ratio for the G allele was 4.95. The frequency of DRB4*0101-positive individuals was significantly higher in HT (odds ratio=2.17). The TSH values of HT patients at the time of diagnosis were compared to CTLA-4 genotype and HLA-DRB4*0101 positivity. They were slightly higher in the CTLA-4-AG group than in the -GG group and significantly higher in the HLA-DRB4*0101-positive group than in the -negative group (p<0.01). When the TSH values were compared in 4 groups based on positivity or negativity for HLA-DRB4*0101 and CTLA-4 GG or AG, they were found to be significantly higher in the CTLA-4-AG and HLA-DRB4*0101-positive group than in the 3 other groups (F=5.75, 3 degrees of freedom, p<0.01). These findings suggest that the interaction between the HLA-DRB4 and CTLA-4 genes determines the thyroid function of TPO-positive goitrous Japanese HT patients.
M Terauchi; T Yanagawa; N Ishikawa; K Ito; T Fukazawa; H Maruyama; T Saruta
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of endocrinological investigation     Volume:  26     ISSN:  0391-4097     ISO Abbreviation:  J. Endocrinol. Invest.     Publication Date:  2003 Dec 
Date Detail:
Created Date:  2004-04-01     Completed Date:  2004-06-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7806594     Medline TA:  J Endocrinol Invest     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  1208-12     Citation Subset:  IM    
Department of Medicine, Keio University, Tokyo, Japan.
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MeSH Terms
Antigens, CD
Antigens, Differentiation / genetics*
Asian Continental Ancestry Group / genetics*
Case-Control Studies
HLA-DR Antigens / genetics*
Polymorphism, Genetic
Thyroid Gland / physiopathology*
Thyroiditis, Autoimmune / blood,  genetics,  physiopathology*
Thyrotropin / blood
Reg. No./Substance:
0/Antigens, CD; 0/Antigens, Differentiation; 0/HLA-DR Antigens; 0/HLA-DRB4; 0/HLA-DRB4*0101 antigen; 0/cytotoxic T-lymphocyte antigen 4; 73-24-5/Adenine; 73-40-5/Guanine; 9002-71-5/Thyrotropin

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