Document Detail


Interactions of HIV, other sexually transmitted diseases, and genital tract inflammation facilitating local pathogen transmission and acquisition.
MedLine Citation:
PMID:  21214660     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Despite several decades of clinical trials assessing the impact of etiological treatment of sexually transmitted diseases (STDs) to decrease HIV acquisition and transmission, almost all of these trials have not proven to be efficacious. Increasing evidence suggests that specific STD treatment alone may not be sufficient to alter the genital tract inflammatory milieu that is created by STDs. This paper examines the associations between STDs and HIV susceptibility and infectiousness, and considers the role of chronic and refractory inflammation to create an environment that potentiates HIV and STD transmission and acquisition by reviewing biological, observational, and clinical trial data.
Authors:
Kenneth H Mayer; Kartik K Venkatesh
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2011-01-09
Journal Detail:
Title:  American journal of reproductive immunology (New York, N.Y. : 1989)     Volume:  65     ISSN:  1600-0897     ISO Abbreviation:  Am. J. Reprod. Immunol.     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-02-07     Completed Date:  2011-08-18     Revised Date:  2013-07-03    
Medline Journal Info:
Nlm Unique ID:  8912860     Medline TA:  Am J Reprod Immunol     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  308-16     Citation Subset:  IM    
Copyright Information:
© 2011 John Wiley & Sons A/S.
Affiliation:
Division of Infectious Diseases, Department of Medicine, Alpert Medical School, Brown University, Providence, RI 02906, USA. kenneth_mayer@brown.edu
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MeSH Terms
Descriptor/Qualifier:
Antiretroviral Therapy, Highly Active
Disease Susceptibility
Drug Interactions
HIV Infections / immunology,  prevention & control,  transmission*
Humans
Inflammation
Sexually Transmitted Diseases* / drug therapy,  immunology,  transmission
Urogenital System* / immunology,  microbiology,  virology
Grant Support
ID/Acronym/Agency:
D43TW000237/TW/FIC NIH HHS; F30 MH079738-01A2/MH/NIMH NIH HHS; F30 MH079738-05/MH/NIMH NIH HHS; P30 AI42853/AI/NIAID NIH HHS; U01 AI069480-05/AI/NIAID NIH HHS
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