| Interactions of HIV, other sexually transmitted diseases, and genital tract inflammation facilitating local pathogen transmission and acquisition. | |
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MedLine Citation:
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PMID: 21214660 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Despite several decades of clinical trials assessing the impact of etiological treatment of sexually transmitted diseases (STDs) to decrease HIV acquisition and transmission, almost all of these trials have not proven to be efficacious. Increasing evidence suggests that specific STD treatment alone may not be sufficient to alter the genital tract inflammatory milieu that is created by STDs. This paper examines the associations between STDs and HIV susceptibility and infectiousness, and considers the role of chronic and refractory inflammation to create an environment that potentiates HIV and STD transmission and acquisition by reviewing biological, observational, and clinical trial data. |
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Authors:
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Kenneth H Mayer; Kartik K Venkatesh |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review Date: 2011-01-09 |
Journal Detail:
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Title: American journal of reproductive immunology (New York, N.Y. : 1989) Volume: 65 ISSN: 1600-0897 ISO Abbreviation: Am. J. Reprod. Immunol. Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-02-07 Completed Date: 2011-08-18 Revised Date: 2012-09-24 |
Medline Journal Info:
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Nlm Unique ID: 8912860 Medline TA: Am J Reprod Immunol Country: Denmark |
Other Details:
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Languages: eng Pagination: 308-16 Citation Subset: IM |
Copyright Information:
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© 2011 John Wiley & Sons A/S. |
Affiliation:
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Division of Infectious Diseases, Department of Medicine, Alpert Medical School, Brown University, Providence, RI 02906, USA. kenneth_mayer@brown.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antiretroviral Therapy, Highly Active Disease Susceptibility Drug Interactions HIV Infections / immunology, prevention & control, transmission* Humans Inflammation Sexually Transmitted Diseases* / drug therapy, immunology, transmission Urogenital System* / immunology, microbiology, virology |
| Grant Support | |
ID/Acronym/Agency:
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D43TW000237/TW/FIC NIH HHS; F30 MH079738-01A2/MH/NIMH NIH HHS; F30 MH079738-05/MH/NIMH NIH HHS; P30 AI42853/AI/NIAID NIH HHS; U01 AI069480-05/AI/NIAID NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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