| Interactions Between HIV-1 and Innate Immunity in Dendritic Cells. | |
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MedLine Citation:
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PMID: 22975876 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Dendritic cells couple pathogen sensing with induction of innate and adaptive immune responses. Pathogen sensing in dendritic cells relies on interactions between molecular patterns of the pathogens and germline-encoded, also referred to as innate, receptors. In this chapter, we analyze some of the interactions between HIV-1 and the innate immune system in dendritic cells. The HIV-1 replication cycle is constituted by an extracellular and an intracellular phase. The two phases of the cycle provide distinct opportunities for interactions with cell-extrinsic and cell-intrinsic mechanisms in dendritic cells. According to the types of dendritic cells, the mechanisms of innate interactions between dendritic cells and HIV-1 lead to specific responses. These innate interactions may contribute to influencing and shaping the adaptive immune response against the virus. |
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Authors:
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Aymeric Silvin; Nicolas Manel |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Advances in experimental medicine and biology Volume: 762 ISSN: 0065-2598 ISO Abbreviation: Adv. Exp. Med. Biol. Publication Date: 2013 |
Date Detail:
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Created Date: 2012-09-14 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0121103 Medline TA: Adv Exp Med Biol Country: United States |
Other Details:
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Languages: eng Pagination: 183-200 Citation Subset: IM |
Affiliation:
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Department of Immunity and Cancer, Institut Curie-INSERM U932, 12 rue Lhomond, Paris, 75011, France. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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