Document Detail

Interactions between the COMT Val108/158Met polymorphism and maternal prenatal smoking predict aggressive behavior outcomes.
MedLine Citation:
PMID:  21356266     Owner:  NLM     Status:  MEDLINE    
The purpose of the current study is to examine the moderating influence of the catechol O methyltransferase gene (COMT) on the maternal prenatal smoking/offspring externalizing disorder relationship. The sample consisted of 430 young adults born between 1981 and 1984 at the Mater Misericordiae Mother's Hospital in Brisbane, Australia, as well as their mothers and peers. Mothers reported their prenatal smoking status during pregnancy, and genetic data was obtained from the youth at a later follow-up in adulthood. The outcome measures in this study were mother and teacher reports of youth attention problems and aggression at age 15, and youth, mother and peer reports of youth attention problems and aggression at age 20 (combined to create latent factors of attention problems and aggression at each age). The COMT Val108/158Met polymorphism (rs4680) significantly interacted with maternal cigarette smoking during pregnancy to predict youth aggressive behavior at ages 15 and 20. This gene-environment interaction was not significant for youth attention problems.
Patricia A Brennan; Constance Hammen; Patrick Sylvers; William Bor; Jake Najman; Penelope Lind; Grant Montgomery; Alicia K Smith
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2011-02-26
Journal Detail:
Title:  Biological psychology     Volume:  87     ISSN:  1873-6246     ISO Abbreviation:  Biol Psychol     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-04-11     Completed Date:  2011-08-04     Revised Date:  2013-06-30    
Medline Journal Info:
Nlm Unique ID:  0375566     Medline TA:  Biol Psychol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  99-105     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier B.V. All rights reserved.
Department of Psychology, 36 Eagle Row, Emory University, Atlanta, GA 30322, USA.
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MeSH Terms
Age Factors
Aggression / physiology
Attention Deficit Disorder with Hyperactivity / etiology,  genetics
Catechol O-Methyltransferase / genetics*
Cohort Studies
Methionine / genetics*
Models, Biological
Polymorphism, Single Nucleotide / genetics*
Prenatal Exposure Delayed Effects*
Smoking / adverse effects*
Valine / genetics*
Young Adult
Grant Support
R01 MH052239/MH/NIMH NIH HHS; R01 MH052239-10/MH/NIMH NIH HHS; R01 MH52239/MH/NIMH NIH HHS
Reg. No./Substance:
63-68-3/Methionine; 7004-03-7/Valine; EC O-Methyltransferase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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