Document Detail

Interaction of type I and type II corticosteroid receptor stimulation on carcass energy and carcass water.
MedLine Citation:
PMID:  8928912     Owner:  NLM     Status:  MEDLINE    
The effects of chronic type I and type II corticosteroid receptor stimulation were examined in adrenalectomized Sprague-Dawley rats to quantify the relative contribution of body energy and body water changes to changes in body weight. Adrenalectomy caused a decrease in both body energy and water. Aldosterone (type I agonist) treatment increased body weight gain and returned energy accretion to the level of sham-operated animals. However, most of the change in body weight (72%) was attributable to a change in body water. The aldosterone-induced increase in body weight gain and carcass water were attenuated by RU-28362 (type II receptor agonist) infusion, suggesting that type II receptor stimulation can antagonize the effect of type I receptor stimulation. Changes in carcass water were paralleled by changes in soluble carcass sodium. Despite alterations in soluble body sodium, no measurable differences in cumulative sodium retention were found. These findings confirm previous studies suggesting an effect of type I receptor stimulation on energy accretion. However, they also caution that changes in body weight cannot be equated with changes in body energy.
B D White; G L Edwards; R J Martin
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of physiology     Volume:  270     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1996 May 
Date Detail:
Created Date:  1996-11-27     Completed Date:  1996-11-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  R1099-108     Citation Subset:  IM    
Department of Foods and Nutrition, University of Georgia, Athens 30602, USA.
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MeSH Terms
Aldosterone / pharmacology
Androstanols / pharmacology
Body Composition / drug effects
Body Water / metabolism*
Body Weight / drug effects
Energy Metabolism* / drug effects
Rats, Sprague-Dawley
Receptors, Steroid / physiology*
Sodium / metabolism
Time Factors
Reg. No./Substance:
0/Androstanols; 0/Receptors, Steroid; 52-39-1/Aldosterone; 7440-23-5/Sodium; 74915-64-3/11,17-dihydroxy-6-methyl-17-(1-propynyl)androsta-1,4,6-triene-3-one

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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