Document Detail


Interaction of transthoracic ultrasound and intravenous microbubbles with cardiac mechanoreceptors.
MedLine Citation:
PMID:  17189056     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The purpose of this study was to examine the effect of transthoracic ultrasound (TTU) and intravenous microbubbles (MB) on cardiac mechanoreceptors. In 16 rabbits (eight normal and eight chronic heart failure), renal sympathetic nerve activity (RSNA), heart rate and mean arterial pressure were examined before, during and after 1 MHz TTU at different peak negative pressures (0.12 to 0.43 MPa) and duty cycles in the presence and absence of perfluorocarbon MB. TTU applications were for 10 s, and the overall duration of MB infusion was approximately 60 s for each setting. TTU without MB had no effect on any parameter. During the microbubble infusion, however, TTU at higher peak negative pressures (> or =0.27 MPa) and 100% duty cycle resulted in a consistent decrease in RSNA(-41 +/- 41% p < 0.001). This was accompanied by brief reflex reductions in mean arterial pressure and heart rate. The changes in RSNA induced by TTU and MB in all rabbits were abolished by vagotomy. TTU, in the presence of MB, stimulates mechanoreceptors in the heart reflexively to reduce RSNA.
Authors:
Feng Xie; Jeane M Tsutsui; Lie Gao; Irving H Zucker; Thomas R Porter
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Ultrasound in medicine & biology     Volume:  33     ISSN:  0301-5629     ISO Abbreviation:  Ultrasound Med Biol     Publication Date:  2007 Jan 
Date Detail:
Created Date:  2006-12-25     Completed Date:  2007-06-28     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0410553     Medline TA:  Ultrasound Med Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  136-44     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine, Section of Cardiology, University of Nebraska Medical Center, Omaha, NE 68198, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Pressure / physiology
Contrast Media
Echocardiography / methods*
Fluorocarbons
Heart Failure / ultrasonography*
Heart Rate / physiology
Male
Mechanoreceptors / physiology*
Microbubbles
Models, Animal
Rabbits
Renal Artery / innervation
Sympathetic Nervous System / physiology
Ultrasonography, Interventional / methods*
Chemical
Reg. No./Substance:
0/Contrast Media; 0/Fluorocarbons

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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