Document Detail

Interaction of soy food and tea consumption with CYP19A1 genetic polymorphisms in the development of endometrial cancer.
MedLine Citation:
PMID:  17827443     Owner:  NLM     Status:  MEDLINE    
Certain polyphenols inhibit the activity of aromatase, a critical enzyme in estrogen synthesis that is coded by the CYP19A1 gene. Consumption of polyphenol-rich foods and beverages, thus, may interact with CYP19A1 genetic polymorphisms in the development of endometrial cancer. The authors tested this hypothesis in the Shanghai Endometrial Cancer Study (1997-2003), a population-based case-control study of 1,204 endometrial cancer cases and 1,212 controls. Dietary information was obtained by use of a validated food frequency questionnaire. Genotypes of CYP19A1 at rs28566535, rs1065779, rs752760, rs700519, and rs1870050 were available for 1,042 cases and 1,035 controls. Unconditional logistic regression models were used to calculate odds ratios and their 95% confidence intervals after adjustment for potential confounding factors. Higher intake of soy foods and tea consumption were both inversely associated with the risk of endometrial cancer, with odds ratios of 0.8 (95% confidence interval: 0.6, 1.0) for the highest versus the lowest tertiles of intake of soy and 0.8 (95% confidence interval: 06, 0.9) for ever tea consumption. The association of single nucleotide polymorphisms rs1065779, rs752760, and rs1870050 with endometrial cancer was modified by tea consumption (p(interaction) < 0.05) but not by soy isoflavone intake. The authors' findings suggest that tea polyphenols may modify the effect of CYP19A1 genetic polymorphisms on the development of endometrial cancer.
Wang Hong Xu; Qi Dai; Yong Bing Xiang; Ji Rong Long; Zhi Xian Ruan; Jia Rong Cheng; Wei Zheng; Xiao Ou Shu
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2007-09-07
Journal Detail:
Title:  American journal of epidemiology     Volume:  166     ISSN:  1476-6256     ISO Abbreviation:  Am. J. Epidemiol.     Publication Date:  2007 Dec 
Date Detail:
Created Date:  2007-11-26     Completed Date:  2008-01-24     Revised Date:  2014-09-12    
Medline Journal Info:
Nlm Unique ID:  7910653     Medline TA:  Am J Epidemiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1420-30     Citation Subset:  IM    
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MeSH Terms
Aromatase / genetics*
Case-Control Studies
China / epidemiology
Endometrial Neoplasms / enzymology*,  epidemiology,  genetics*
Middle Aged
Odds Ratio
Polymorphism, Genetic*
Risk Factors
Soy Foods*
Grant Support
R01 CA092585/CA/NCI NIH HHS; R01 CA092585-05/CA/NCI NIH HHS; R01CA92585/CA/NCI NIH HHS
Reg. No./Substance:
0/Tea; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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