| Interaction of sevoflurane, isoflurane, enflurane and halothane with non-depolarizing muscle relaxants and their prejunctional effects at the neuromuscular junction. | |
| | |
MedLine Citation:
|
PMID: 1978766 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The interaction of four inhalational anesthetics (sevoflurane, isoflurane, enflurane and halothane) with pancuronium and vecuronium and also their prejunctional actions at the neuromuscular junction were quantitatively studied using rat phrenic nerve-hemidiaphragm preparations. To investigate the prejunctional effects of inhalational anesthetics, a train-of-four ratio (T4/T1) and the tetanus ratio (the ratio of the final response to the initial response during tetanus) were evaluated. All four inhalational anesthetics markedly potentiated the neuromuscular blockade of twitch response caused by either pancuronium or vecuronium with halothane and enflurane being the most potent both on a % concentration basis and on a MAC (minimum alveolar concentration) basis. Although none of the four inhalational anesthetics had any effects on the T4/T1 ratio, they produced variable effects on the tetanus ratio. Sevoflurane had little effect on the tetanus ratio, whereas 1 and 2% isoflurane and 1, 2 and 3% enflurane increased the tetanus ratio and 5% halothane and 5% enflurane significantly reduced the tetanus ratio. Halothane and enflurane had the most potent depressant action of the four inhalational anesthetics both on the % concentration basis and on the MAC basis. These results indicate that the main site of action of inhalational anesthetics is a postjunctional site at the neuromuscular junction and that they do not seem to act on prejunctional sites at the concentrations used in clinical situations. |
| | |
Authors:
|
O Kobayashi; Y Ohta; F Kosaka |
Related Documents
:
|
1973636 - Neuromuscular and cardiovascular effects of pipecuronium. 8260296 - Single space combined spinal-extradural technique for analgesia in labour. 15278576 - The neuromuscular effects of sevoflurane and isoflurane alone and in combination with v... 15108076 - Jugular venous oxygen saturation during mild hypothermic versus normothermic cardiopulm... 8871906 - Physiological adaptations and countermeasures associated with long-duration spaceflights. 18581066 - Strontium levels in different causes of death: diagnostic efficacy in drowning. |
Publication Detail:
|
Type: In Vitro; Journal Article |
Journal Detail:
|
Title: Acta medica Okayama Volume: 44 ISSN: 0386-300X ISO Abbreviation: Acta Med. Okayama Publication Date: 1990 Aug |
Date Detail:
|
Created Date: 1991-01-02 Completed Date: 1991-01-02 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0417611 Medline TA: Acta Med Okayama Country: JAPAN |
Other Details:
|
Languages: eng Pagination: 209-15 Citation Subset: IM |
Affiliation:
|
Department of Anesthesiology and Resuscitology, Okayama University Medical School, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Anesthetics
/
pharmacology* Animals Drug Synergism Enflurane / pharmacology Ethers / pharmacology Halothane / pharmacology Isoflurane / pharmacology Male Methyl Ethers* Neuromuscular Junction / drug effects* Pancuronium / pharmacology* Rats Rats, Inbred Strains Vecuronium Bromide / pharmacology* |
| Chemical | |
Reg. No./Substance:
|
0/Anesthetics; 0/Ethers; 0/Methyl Ethers; 0/Pancuronium; 13838-16-9/Enflurane; 151-67-7/Halothane; 26675-46-7/Isoflurane; 28523-86-6/sevoflurane; 50700-72-6/Vecuronium Bromide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Postanaesthetic nausea in children.
Next Document: Effect of procaterol on arterial blood gas in asthmatic children.