Document Detail

Interaction of sevoflurane, isoflurane, enflurane and halothane with non-depolarizing muscle relaxants and their prejunctional effects at the neuromuscular junction.
MedLine Citation:
PMID:  1978766     Owner:  NLM     Status:  MEDLINE    
The interaction of four inhalational anesthetics (sevoflurane, isoflurane, enflurane and halothane) with pancuronium and vecuronium and also their prejunctional actions at the neuromuscular junction were quantitatively studied using rat phrenic nerve-hemidiaphragm preparations. To investigate the prejunctional effects of inhalational anesthetics, a train-of-four ratio (T4/T1) and the tetanus ratio (the ratio of the final response to the initial response during tetanus) were evaluated. All four inhalational anesthetics markedly potentiated the neuromuscular blockade of twitch response caused by either pancuronium or vecuronium with halothane and enflurane being the most potent both on a % concentration basis and on a MAC (minimum alveolar concentration) basis. Although none of the four inhalational anesthetics had any effects on the T4/T1 ratio, they produced variable effects on the tetanus ratio. Sevoflurane had little effect on the tetanus ratio, whereas 1 and 2% isoflurane and 1, 2 and 3% enflurane increased the tetanus ratio and 5% halothane and 5% enflurane significantly reduced the tetanus ratio. Halothane and enflurane had the most potent depressant action of the four inhalational anesthetics both on the % concentration basis and on the MAC basis. These results indicate that the main site of action of inhalational anesthetics is a postjunctional site at the neuromuscular junction and that they do not seem to act on prejunctional sites at the concentrations used in clinical situations.
O Kobayashi; Y Ohta; F Kosaka
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Acta medica Okayama     Volume:  44     ISSN:  0386-300X     ISO Abbreviation:  Acta Med. Okayama     Publication Date:  1990 Aug 
Date Detail:
Created Date:  1991-01-02     Completed Date:  1991-01-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0417611     Medline TA:  Acta Med Okayama     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  209-15     Citation Subset:  IM    
Department of Anesthesiology and Resuscitology, Okayama University Medical School, Japan.
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MeSH Terms
Anesthetics / pharmacology*
Drug Synergism
Enflurane / pharmacology
Ethers / pharmacology
Halothane / pharmacology
Isoflurane / pharmacology
Methyl Ethers*
Neuromuscular Junction / drug effects*
Pancuronium / pharmacology*
Rats, Inbred Strains
Vecuronium Bromide / pharmacology*
Reg. No./Substance:
0/Anesthetics; 0/Ethers; 0/Methyl Ethers; 0/Pancuronium; 13838-16-9/Enflurane; 151-67-7/Halothane; 26675-46-7/Isoflurane; 28523-86-6/sevoflurane; 50700-72-6/Vecuronium Bromide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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