Document Detail

Interaction of retinoblastoma gene product with transcription factors ATFa and ATF2.
MedLine Citation:
PMID:  7786026     Owner:  NLM     Status:  MEDLINE    
Two highly related transcription factors, activating transcription factors a and 2 (ATFa and ATF2) are able to activate expression in CHO cells of a reporter gene driven by the human transforming growth factor beta 2 gene promoter. This action is dependent on the intact motif CGTCA which is found as part of the cAMP responsive element in a number of promoters and to which both factors can bind in vitro. The retinoblastoma gene product also weakly stimulates expression of this reporter gene but, in combination with the factors, it exhibits a differential action: additive or greater stimulatory effects with ATF2 but strong inhibition of the actions of ATFa. Thus, although both of these two related factors are able to exert the same apparent effect on this promoter, coexpression of the retinoblastoma gene product reveals at least one significant difference in their actions.
Q Gong; Z Huang; W D Wicks
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Archives of biochemistry and biophysics     Volume:  319     ISSN:  0003-9861     ISO Abbreviation:  Arch. Biochem. Biophys.     Publication Date:  1995 Jun 
Date Detail:
Created Date:  1995-07-17     Completed Date:  1995-07-17     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0372430     Medline TA:  Arch Biochem Biophys     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  445-50     Citation Subset:  IM    
Department of Biochemistry, University of Tennessee, Knoxville 37996, USA.
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MeSH Terms
Activating Transcription Factor 1
Activating Transcription Factor 2
Binding Sites / genetics
CHO Cells
Cyclic AMP Response Element-Binding Protein / genetics,  metabolism*
DNA-Binding Proteins*
Gene Expression Regulation
Gene Transfer Techniques
Promoter Regions, Genetic / genetics
Retinoblastoma Protein / metabolism*
Transcription Factors / genetics,  metabolism*
Transforming Growth Factor beta / genetics
Grant Support
7088//PHS HHS
Reg. No./Substance:
0/Activating Transcription Factor 1; 0/Activating Transcription Factor 2; 0/Cyclic AMP Response Element-Binding Protein; 0/DNA-Binding Proteins; 0/Retinoblastoma Protein; 0/Transcription Factors; 0/Transforming Growth Factor beta

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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