| Interaction and relationship between angiotensin converting enzyme gene and environmental factors predisposing to essential hypertension in Mongolian population of China. | |
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MedLine Citation:
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PMID: 15386943 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To investigate the association of specific functional gene ACE (I/D) variants of the renin-angiotensin system with essential hypertension (EH) and interaction between ACE (I/D) gene and risk factors for EH in a genetically homogenous Mongolia rural population of China. METHODS: Individuals (n=1099) were recruited from general population of Kezuohouqi Banner in Inner Mongolian Autonomous Region. RESULTS: The association was found between ACE genotype DD plus ID and EH, with an interaction between ACE genotype DD plus ID and cigarette smoking in an additive model. Cigarette smoking index and ACE gene showed a low exposure-gene (LEG) effect on EH, with interaction indices from 7.10 to 1.16. Interaction between ACE genotype DD plus ID and alcohol drinking on EH appeared an additive model. Alcohol drinking index and ACE gene showed a low exposure-gene (LEG) effect on EH, with interaction indices from 1.66 to 1.09. BMI and ACE gene showed a low exposure-gene (LEG) effect on EH, with interaction indices from 6.15 to 2.49. Interactions between ACE genotype and WHR on EH showed a multiplicative model. In a short,there was an interaction between ACE gene and cigarette smoking, alcohol drinking and BMI on EH, especially in a low dose-exposure effect CONCLUSION: It is important for individuals who carry ACE D allele gene to prevent EH, and furthermore, to prevent and control coronary heart disease, in a view of population-based prevention. |
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Authors:
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Qun Xu; Yan-Hua Wang; Wei-Jun Tong; Ming-Liang Gu; Gang Wu; Batu Buren; Yong-Yue Liu; Jian Wang; Yong-Shan Li; Hua Feng; Shuang-Lian Bai; Hai-Hua Pang; Gui-Rong Huang; Ming-Wu Fang; Yong-Hong Zhang; Zheng-Lai Wu; Chang-Chun Qiu |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Biomedical and environmental sciences : BES Volume: 17 ISSN: 0895-3988 ISO Abbreviation: Biomed. Environ. Sci. Publication Date: 2004 Jun |
Date Detail:
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Created Date: 2004-09-24 Completed Date: 2004-12-10 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8909524 Medline TA: Biomed Environ Sci Country: United States |
Other Details:
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Languages: eng Pagination: 177-86 Citation Subset: IM |
Affiliation:
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National Laboratory of Medical Molecular Biology, School of Basic Medicine, Peking College, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Beijing 100005, China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Age Factors Alcohol Drinking Anthropometry Blood Glucose China Cholesterol / blood Cross-Sectional Studies Environmental Exposure* Female Genetic Predisposition to Disease Humans Hypertension / enzymology, etiology, genetics* Male Middle Aged Mongolia / ethnology Peptidyl-Dipeptidase A / genetics* Polymorphism, Genetic* Renin-Angiotensin System / genetics Risk Factors Rural Population Sex Factors Smoking Triglycerides / blood |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Triglycerides; 57-88-5/Cholesterol; EC 3.4.15.1/Peptidyl-Dipeptidase A |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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