| Interaction of reactive oxygen and nitrogen species with albumin- and methemoglobin-bound dinitrosyl-iron complexes. | |
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MedLine Citation:
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PMID: 18036856 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Destructive effect of superoxide anions O2- derived from KO(2) or xanthine-xanthine oxidase system on dinitrosyl-iron complexes bound with bovine albumin or methemoglobin (DNIC-BSA or DNIC-MetHb) was demonstrated. The sensitivity of DNIC-BSA synthesized by the addition of DNIC with cysteine, thiosulfate or phosphate (DNIC-BSA-1, DNIC-BSA-2 or DNIC-BSA-3, respectively) to destructive action of O2- decreased in row: DNIC-BSA-1>DNIC-BSA-3>DNIC-BSA-2. The estimated rate constant for the reaction between O2- and DNIC-BSA-3 was equal to approximately 10(7)M(-1)s(-1). However, hydrogen peroxide and tert-butyl hydrogenperoxide (t-BOOH) did not induce any noticeable degradation of DNIC-BSA-3 even when used at concentrations exceeding by one order of magnitude those of the complex. As to their action on DNIC-MetHb both hydrogen peroxide and t-BOOH-induced rapid degradation of the complex. Both agents could induce the process due to the effect of alkylperoxyl or protein-derived free radicals formed at the interaction of the agents with ferri-heme groups of MetHb. Peroxynitrite (ONOO(-)) could also initiate protein-bound DNIC degradation more efficiently in the reaction with DNIC-BSA-3. Higher resistance of DNIC-MetHb to peroxynitrite was most probably due to the protective action of heme groups on ONOO(-). However, the analysis allows to suggest that the interaction of protein-bound DNICs with O2- is the only factor responsible for the degradation of the complexes in cells and tissues. |
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Authors:
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Konstantin B Shumaev; Andrey A Gubkin; Vladimir A Serezhenkov; Irina I Lobysheva; Olga V Kosmachevskaya; Enno K Ruuge; Vadim Z Lankin; Alexey F Topunov; Anatoly F Vanin |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-10-01 |
Journal Detail:
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Title: Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society Volume: 18 ISSN: 1089-8603 ISO Abbreviation: Nitric Oxide Publication Date: 2008 Feb |
Date Detail:
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Created Date: 2007-12-31 Completed Date: 2008-05-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9709307 Medline TA: Nitric Oxide Country: United States |
Other Details:
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Languages: eng Pagination: 37-46 Citation Subset: IM |
Affiliation:
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Russian Cardiological Research-and-Production Complex, Moscow, Russian Federation. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cattle Hydrogen Peroxide / chemistry Iron / chemistry* Methemoglobin / chemistry* Nitrogen Oxides / chemistry* Peroxynitrous Acid / chemistry Reactive Nitrogen Species / chemistry* Reactive Oxygen Species / chemistry* Serum Albumin, Bovine / chemistry* Time Factors tert-Butylhydroperoxide / chemistry |
| Chemical | |
Reg. No./Substance:
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0/Nitrogen Oxides; 0/Reactive Nitrogen Species; 0/Reactive Oxygen Species; 0/Serum Albumin, Bovine; 14691-52-2/Peroxynitrous Acid; 68586-27-6/dinitrosyl iron complex; 7439-89-6/Iron; 75-91-2/tert-Butylhydroperoxide; 7722-84-1/Hydrogen Peroxide; 9008-37-1/Methemoglobin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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