| Interaction of radiation and pemetrexed on a human malignant mesothelioma cell line in vitro. | |
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MedLine Citation:
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PMID: 21868528 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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MATERIALS AND METHODS: The toxic effects of treatment with radiation and/or pemetrexed (PEM) on NCI-H28 cells were assessed by clonogenic assay. TUNEL/DAPI staining was used to measure the apoptosis index (AI). Thymidylate synthase (TS) protein expression was measured by Western blotting. RESULTS: The D0 value of the combination treatment was lower than that for radiation, indicating its addition resulted in the synergistic effects with radiation. An increase in AI was observed with the combination compared with that observed after PEM alone. Radiation induced a time-dependent decrease in TS expression. Increased TS expression was observed after PEM, but the combination treatment decreased TS expression. CONCLUSION: Treatment with pemetrexed in combination with radiation has a supra-additive effect, partially due to the synergistic induction of apoptosis, which may be due to TS suppression, by the irradiation enhancing the effect of pemetrexed. |
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Authors:
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Daisaku Yoshida; Takeshi Ebara; Yumi Sato; Takuya Kaminuma; Takeo Takahashi; Takayuki Asao; Takashi Nakano |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Anticancer research Volume: 31 ISSN: 1791-7530 ISO Abbreviation: Anticancer Res. Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-08-26 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8102988 Medline TA: Anticancer Res Country: Greece |
Other Details:
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Languages: eng Pagination: 2847-51 Citation Subset: IM |
Affiliation:
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Department of Radiation Oncology, Gunma University, Graduate School of Medicine, 3-39-22, Showa-machi, Maebashi, Gunma 371-8511, Japan. daisakuy@med.gunma-u.ac.jp. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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