Document Detail

Interaction of quinidine and propranolol in experimental cardiac arrhythmias in the dog.
MedLine Citation:
PMID:  849075     Owner:  NLM     Status:  MEDLINE    
Quinidine, propranolol and their combination were studied in atrial fibrillation induced by the topical application of acetylcholine or aconitine, injury-stimulation-induced atrial flutter and ventricular ectopic tachycardia produced by coronary occlusion in the dog. The effect of combination of quinidine and propranolol was significantly greater than that of the individual drug in atrial arrhythmias but not in ventricular arrhythmias. The study provides experimental support for the combined clinical use of quinidine and propranolol in the treatment of atrial arrhythmias.
B R Madan; V K Pendse
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Archives internationales de pharmacodynamie et de thérapie     Volume:  225     ISSN:  0003-9780     ISO Abbreviation:  Arch Int Pharmacodyn Ther     Publication Date:  1977 Feb 
Date Detail:
Created Date:  1977-05-25     Completed Date:  1977-05-25     Revised Date:  2012-01-12    
Medline Journal Info:
Nlm Unique ID:  0405353     Medline TA:  Arch Int Pharmacodyn Ther     Country:  BELGIUM    
Other Details:
Languages:  eng     Pagination:  287-93     Citation Subset:  IM    
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MeSH Terms
Aconitine / pharmacology
Anti-Arrhythmia Agents*
Atrial Fibrillation / chemically induced,  physiopathology
Drug Interactions
Electric Stimulation
Heart / physiology
Propranolol / pharmacology*
Quinidine / pharmacology*
Ventricular Fibrillation / physiopathology
Reg. No./Substance:
0/Anti-Arrhythmia Agents; 302-27-2/Aconitine; 51-84-3/Acetylcholine; 525-66-6/Propranolol; 56-54-2/Quinidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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