Document Detail


Interaction of quinidine and propranolol in experimental cardiac arrhythmias in the dog.
MedLine Citation:
PMID:  849075     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Quinidine, propranolol and their combination were studied in atrial fibrillation induced by the topical application of acetylcholine or aconitine, injury-stimulation-induced atrial flutter and ventricular ectopic tachycardia produced by coronary occlusion in the dog. The effect of combination of quinidine and propranolol was significantly greater than that of the individual drug in atrial arrhythmias but not in ventricular arrhythmias. The study provides experimental support for the combined clinical use of quinidine and propranolol in the treatment of atrial arrhythmias.
Authors:
B R Madan; V K Pendse
Related Documents :
2346965 - Electrophysiological effects of acetylcholine in purkinje fibres surviving infarction.
6695815 - Antiarrhythmic and electrophysiologic actions of flecainide in animal models.
67335 - Antiarrhythmic action of lignocaine in early myocardial infarction. plasma levels after...
7903545 - Pancuronium, vecuronium, and heart rate during anesthesia for aortocoronary bypass oper...
8462135 - Coronary artery size and dilating capacity in ultradistance runners.
7317905 - Prognostic value of thallium-201 stress myocardial scintigraphy with exercise ecg after...
Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Archives internationales de pharmacodynamie et de thérapie     Volume:  225     ISSN:  0003-9780     ISO Abbreviation:  Arch Int Pharmacodyn Ther     Publication Date:  1977 Feb 
Date Detail:
Created Date:  1977-05-25     Completed Date:  1977-05-25     Revised Date:  2012-01-12    
Medline Journal Info:
Nlm Unique ID:  0405353     Medline TA:  Arch Int Pharmacodyn Ther     Country:  BELGIUM    
Other Details:
Languages:  eng     Pagination:  287-93     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Acetylcholine
Aconitine / pharmacology
Animals
Anti-Arrhythmia Agents*
Atrial Fibrillation / chemically induced,  physiopathology
Dogs
Drug Interactions
Electric Stimulation
Female
Heart / physiology
Male
Propranolol / pharmacology*
Quinidine / pharmacology*
Ventricular Fibrillation / physiopathology
Chemical
Reg. No./Substance:
0/Anti-Arrhythmia Agents; 302-27-2/Aconitine; 51-84-3/Acetylcholine; 525-66-6/Propranolol; 56-54-2/Quinidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Some pharmacological studies on the cardiotonic effects of furanosteroidal glycosides.
Next Document:  Effects of reticular stimulation, d-amphetamine and scopolamine on acetylcholine release from the hi...