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Interaction proteomics of the AMPA receptor: towards identification of receptor sub-complexes.
MedLine Citation:
PMID:  23344883     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
AMPA receptors (AMPAR) are the main ligand-gated ion channels responsible for the fast excitatory synaptic transmission in the mammalian brain. Whereas a number of proteins that interact with AMPAR are known to be involved in the trafficking and localization of the receptor and/or the regulation of receptor channel properties, the protein composition of the AMPAR supra-complexes are largely unclear. Recent interaction proteomics report the presence of up to 34 proteins as high-confidence constituents of the AMPAR. It was proposed that the inner core of the receptor complex consists of the GluA tetramer and four auxiliary proteins comprising transmembrane AMPA receptor regulatory proteins and/or cornichons. The other AMPAR interactors, present in lower amount, may form the outer shell of the AMPAR with a range in size and variability.
Authors:
Ka Wan Li; Ning Chen; August B Smit
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-24
Journal Detail:
Title:  Amino acids     Volume:  -     ISSN:  1438-2199     ISO Abbreviation:  Amino Acids     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9200312     Medline TA:  Amino Acids     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Molecular and Cellular Neurobiology, Faculty of Earth and Life Sciences, Center for Neurogenomics and Cognitive Research, Neuroscience Campus Amsterdam, VU University, De Boelelaan 1085, Amsterdam, 1081 HV, The Netherlands, ka.wan.li@falw.vu.nl.
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