| Interaction of p53 with Tumor Suppressive and Oncogenic Signaling Pathways to Control Cellular Reactive Oxygen Species Production. | |
| | |
MedLine Citation:
|
PMID: 20919943 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Abstract p53 is a crucial transcription factor with tumor suppressive properties that elicits its function through specific target genes. It constitutes a pivotal system that integrates information received by many signaling pathways and subsequently orchestrates cell fate decisions, namely, growth-arrest, senescence, or apoptosis. Reactive oxygen species (ROS) production in cells can play a key role in signal transduction, being able to trigger different processes as cell death or cell proliferation. Sustained oxidative stress can induce genomic instability and collaborates with cancer development, whereas acute enhancement of high ROS levels leads to toxic oxidative cell damage and cell death. Here, it has been considered p53 broad potential contribution through its ability to regulate selected key cancer signaling pathways, where ROS participate as inductors or effectors of the final biological outcome. Further, we have discussed how p53 could play a role in preventing potentially harmful oxidative state and cell proliferation by pro-oncogenic pathways such as PI3K/AKT/mTOR and WNT/β-catenin or under hypoxia state. In addition, we have considered potential mechanisms by which p53 could collaborate with signal transduction pathways such as transforming growth factor-β (TGF-β) and stress-activated protein kinases (SAPK) that produce ROS, to stop or eliminate uncontrolled proliferating cells. Antioxid. Redox Signal. 15, 1749-1761. |
| | |
Authors:
|
María Fátima Ladelfa; María Fernanda Toledo; Julieta Eva Laiseca; Martín Monte |
Related Documents
:
|
17581813 - Mechanism of cell death caused by complex i defects in a rat dopaminergic cell line. 12185583 - Dna damage, death receptor activation and reactive oxygen species contribute to ultravi... 7606873 - Induction of interleukin-1 receptor antagonist (il-1ra) following surgery is associated... |
Publication Detail:
|
Type: Journal Article Date: 2011-04-14 |
Journal Detail:
|
Title: Antioxidants & redox signaling Volume: 15 ISSN: 1557-7716 ISO Abbreviation: Antioxid. Redox Signal. Publication Date: 2011 Sep |
Date Detail:
|
Created Date: 2011-08-08 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 100888899 Medline TA: Antioxid Redox Signal Country: United States |
Other Details:
|
Languages: eng Pagination: 1749-61 Citation Subset: IM |
Affiliation:
|
Laboratorio de Biología Celular y Molecular, Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires , Buenos Aires, Argentina . |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: p53, Aerobic Metabolism, and Cancer.
Next Document: Determinants of absence of osteoarthritis in old age.