| Interaction of methoxamine with compensatory vasodilation distal to coronary stenoses. | |
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MedLine Citation:
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PMID: 6320837 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The interaction of alpha 1-receptor mediated vasoconstriction with the compensatory vasodilation distal to coronary stenoses was examined in 9 open-chest dogs. Stenoses on proximal circumflex artery were produced by a circumferential wire snare; an intermediate stenosis was defined by reduction of the reactive hyperemia repayment to 70%, a critical stenosis by prevention of any repayment following a 15-s occlusion. Methoxamine (Vasoxine), 500 micrograms, was infused via a small catheter distal to the stenosis under a constant coronary perfusion pressure of 80 mmHg and a constant heart rate of 160 bpm. The vasoconstrictive response to methoxamine correlated with the degree of reactive hyperemia repayment after 15 s occlusion (r = 0.74) and the preexisting level of poststenotic resistance (r = 0.62). At increasing peripheral coronary pressure distal to the stenosis the resistance of the stenosis was reduced (r = -0.84). Thus, alpha 1-adrenergic vasoconstriction is less marked with increasing compensatory vasodilation distal to coronary stenosis. The severity of the stenosis is reduced at increased intraluminal pressure, probably by distention of its luminal area. Methoxamine might induce a redistribution of coronary blood flow towards ischemic regions and reduce ischemic injury. |
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Authors:
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G Heusch; N Yoshimoto; H Heegemann; V Thämer |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Arzneimittel-Forschung Volume: 33 ISSN: 0004-4172 ISO Abbreviation: Arzneimittelforschung Publication Date: 1983 |
Date Detail:
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Created Date: 1984-03-01 Completed Date: 1984-03-01 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0372660 Medline TA: Arzneimittelforschung Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 1647-50 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Coronary Circulation / drug effects* Coronary Disease / physiopathology* Dogs Female Male Methoxamine / pharmacology* Receptors, Adrenergic, alpha / drug effects, physiology Vasodilation / drug effects* |
| Chemical | |
Reg. No./Substance:
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0/Receptors, Adrenergic, alpha; 390-28-3/Methoxamine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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