Document Detail

Interaction of leptin and nitric oxide on food intake in broilers and Leghorns.
MedLine Citation:
PMID:  17631366     Owner:  NLM     Status:  MEDLINE    
Leptin, which is produced in proportion to adiposity, has been reported to regulate feeding behaviors. Previous researchers reported that inhibition of nitric oxide (NO) synthase (NOS) decreased food intake, while L-arginine attenuated this effect. Recently, studies showed that NO plays an important role as a mediator of feeding behavior induced by a variety of neuropeptides. We investigated whether the anorectic effect of leptin is mediated by nitric oxide in broilers and Leghorns. In the first experiment, leptin was intracerebroventricularly (ICV) administered into the right lateral ventricle of broilers and food intake monitored at 15-min intervals through 180 min postinjection. L-arginine attenuated the decrease in food intake induced by leptin. In the second experiment, leptin was coinjected ICV with NG-nitro-arginine methyl ester HC1 (L-NNA), a NOS inhibitor. In the following study, we investigated whether the decreased feeding induced by leptin (10 microg/l0 microl) is mediated by nitric oxide in chickens. Three week old chickens were administered two levels of leptin (A=aCSF, B=10 microg/l0 microl) into the right lateral ventricle, and nitrate and nitrite (nitric oxide metabolites) were monitored 30-min postinjection. The results showed leptin decreased NO formation significantly compared with the control group. These results suggest that NO interacts with leptin in the central nervous system to modulate feeding behavior in the chicken.
S J Yang; D M Denbow
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Publication Detail:
Type:  Journal Article     Date:  2007-05-18
Journal Detail:
Title:  Physiology & behavior     Volume:  92     ISSN:  0031-9384     ISO Abbreviation:  Physiol. Behav.     Publication Date:  2007 Nov 
Date Detail:
Created Date:  2007-11-05     Completed Date:  2008-01-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0151504     Medline TA:  Physiol Behav     Country:  United States    
Other Details:
Languages:  eng     Pagination:  651-7     Citation Subset:  IM    
Department of Neurology, Mount Sinai School of Medicine, New York, NY 10021, United States.
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MeSH Terms
Analysis of Variance
Appetite Regulation / physiology*
Arginine / metabolism,  physiology*
Chickens / physiology*
Eating / physiology*
Enzyme Inhibitors / pharmacology
Feeding Behavior / physiology
Injections, Intraventricular
Leptin / administration & dosage,  physiology*
NG-Nitroarginine Methyl Ester / pharmacology
Nitric Oxide / metabolism
Nitric Oxide Synthase / drug effects,  metabolism*
Random Allocation
Recombinant Proteins
Reg. No./Substance:
0/Enzyme Inhibitors; 0/Leptin; 0/Recombinant Proteins; 10102-43-9/Nitric Oxide; 50903-99-6/NG-Nitroarginine Methyl Ester; 74-79-3/Arginine; EC Oxide Synthase

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