Document Detail


Interaction of heat with X-rays and cis-platinum; cell lethality and oncogenic transformation.
MedLine Citation:
PMID:  2592783     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
There is increasing concern for the oncogenic potential of agents used to treat cancer. Hyperthermia is one of the few modalities that does not, of itself, produce transformed foci in vitro. The adjuvant use of heat with X-rays or chemotherapy agents is an interesting approach to increasing the cell-killing potential while decreasing the oncogenicity of combined-modality therapy. Following a priming heat dose in C3H 10T1/2 cells, resistance to cell killing by a second heat dose develops and is maximal by 10 h. This is known as thermotolerance, and can be monitored by the appearance of proteins of specific molecular weight known as heat-shock proteins. By contrast, a priming heat dose does not confer resistance to killing by cis-platinum (cis-DDP). Indeed, heat potentiates the cytotoxicity due to cis-DDP. The interaction is greatest if heat and drug are applied simultaneously, but is still substantial if the drug is applied many hours after heating. The loss of interaction between heat and cis-DDP occurs slowly, but by 48 h, heat and drug act independently. Thermotolerant cells are less sensitive to the induction of transformation by X-rays than previously unheated cells. On the other hand, 48 h after a heat exposure, when cells have regained their normal sensitivity to killing by cis-DDP, their sensitivity to the induction of transformation by cis-DDP has also returned to normal.
Authors:
R C Miller; L Roizin-Towle; K Komatsu; M Richards; E J Hall
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group     Volume:  5     ISSN:  0265-6736     ISO Abbreviation:  Int J Hyperthermia     Publication Date:    1989 Nov-Dec
Date Detail:
Created Date:  1990-01-16     Completed Date:  1990-01-16     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8508395     Medline TA:  Int J Hyperthermia     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  697-705     Citation Subset:  IM    
Affiliation:
Radiological Research Laboratories, College of Physicians & Surgeons of Columbia University, New York, NY 10032.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Line
Cell Survival / drug effects,  physiology*,  radiation effects
Cell Transformation, Neoplastic* / chemically induced,  radiation effects
Cisplatin / toxicity*
Combined Modality Therapy
Heat-Shock Proteins / biosynthesis
Hyperthermia, Induced*
Grant Support
ID/Acronym/Agency:
CA 43130/CA/NCI NIH HHS; CA 43194/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Heat-Shock Proteins; 15663-27-1/Cisplatin
Comments/Corrections
Erratum In:
Int J Hyperthermia 1990 Mar-Apr;6(2):474

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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